Tina Jafari1, Aziz A Fallah2, Afshin Barani3. 1. Department of Biochemistry and Nutrition, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran; Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharhekord, Iran. Electronic address: tinajafari15@yahoo.com. 2. Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord 34141, Iran. 3. Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Abstract
BACKGROUND & AIMS: The effect of vitamin D on lipid profile in type 2 diabetic patients is controversial. This meta-analysis aimed to assess the effect of vitamin D on serum total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) of these patients to elucidate the subject. METHODS: Seven databases were searched and randomized controlled trials (RCTs) assessed the effect of vitamin D on lipid profile published until November 2015 were identified. Un-standardized mean difference and its corresponding 95% confidence interval (CI) was calculated from the effect sizes by using random effects model. RESULTS: We found 2220 articles in our systematic search, after exclusion of un-related studies we enrolled 17 studies comparing intervention group (received vitamin D) with control group (received placebo) in the meta-analysis. Vitamin D significantly reduced serum TC (-3.74 mg/dl, 95% CI: -7.13 to -0.34, P = 0.031), but serum TG did not show significant reduction (-4.90 mg/dl, 95% CI: -15.11-5.31, P = 0.347). Results confirmed the significant lowering effect of vitamin D on LDL in patients with T2D (-2.55 mg/dl, 95% CI: -4.83 to -0.26, P = 0.029), but change in serum HDL was negligible (-0.72 mg/dl, 95% CI: -1.27 to -0.17, P = 0.010). Subgroup analyses showed that the baseline serum 25-hydroxy vitamin D of patients, vitamin D dosage, intervention duration, and the method of vitamin D application influence the effect of vitamin D on lipid markers. CONCLUSION: This study demonstrated that vitamin D improved serum levels of TC, TG, and LDL in patients with T2D but changes of serum HDL was not satisfactory.
BACKGROUND & AIMS: The effect of vitamin D on lipid profile in type 2 diabeticpatients is controversial. This meta-analysis aimed to assess the effect of vitamin D on serum total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) of these patients to elucidate the subject. METHODS: Seven databases were searched and randomized controlled trials (RCTs) assessed the effect of vitamin D on lipid profile published until November 2015 were identified. Un-standardized mean difference and its corresponding 95% confidence interval (CI) was calculated from the effect sizes by using random effects model. RESULTS: We found 2220 articles in our systematic search, after exclusion of un-related studies we enrolled 17 studies comparing intervention group (received vitamin D) with control group (received placebo) in the meta-analysis. Vitamin D significantly reduced serum TC (-3.74 mg/dl, 95% CI: -7.13 to -0.34, P = 0.031), but serum TG did not show significant reduction (-4.90 mg/dl, 95% CI: -15.11-5.31, P = 0.347). Results confirmed the significant lowering effect of vitamin D on LDL in patients with T2D (-2.55 mg/dl, 95% CI: -4.83 to -0.26, P = 0.029), but change in serum HDL was negligible (-0.72 mg/dl, 95% CI: -1.27 to -0.17, P = 0.010). Subgroup analyses showed that the baseline serum 25-hydroxy vitamin D of patients, vitamin D dosage, intervention duration, and the method of vitamin D application influence the effect of vitamin D on lipid markers. CONCLUSION: This study demonstrated that vitamin D improved serum levels of TC, TG, and LDL in patients with T2D but changes of serum HDL was not satisfactory.
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