| Literature DB >> 27020522 |
Kyle H Rohde1, Heather A Michaels2, Adel Nefzi3.
Abstract
Parallel solid phase synthesis offers a unique opportunity for the synthesis and screening of large numbers of compounds and significantly enhances the prospect of finding new leads. We report the synthesis and antitubercular activity of chiral 1,2,4-trisubstituted piperazines derived from resin bound acylated dipeptides against Mycobacterium tuberculosis strain H37Rv.Entities:
Keywords: Antitubercular; Combinatorial chemistry; Solid phase synthesis; Substituted piperazines
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Year: 2016 PMID： 27020522 DOI： 10.1016/j.bmcl.2016.03.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823