| Literature DB >> 27020305 |
Han-Xun Wei1, Dai Lu1, Vivien Sun1, Jing Zhang1, Yongli Gu1, Pamela Osenkowski1, Wenjuan Ye1, Dennis J Selkoe1, Michael S Wolfe1, Corinne E Augelli-Szafran2.
Abstract
One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the beginning of a series of studies from our laboratories, a series of novel γ-amino alcohols (1) were found to possess γ-secretase inhibitory activity and Notch-sparing effects. A new one-pot synthesis of γ-amino alcohols and the structure-activity relationship (SAR) of these analogs will be discussed.Entities:
Keywords: Alzheimer’s disease; Aβ production; Notch-processing; γ-Amino alcohols; γ-Secretase inhibitors
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Year: 2016 PMID： 27020305 PMCID： PMC8323768 DOI： 10.1016/j.bmcl.2016.03.042
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823