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Literature DB >> 27020300

Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting.

Akihiro Ogura¹, Tsuyoshi Tahara², Satoshi Nozaki², Hirotaka Onoe², Almira Kurbangalieva³, Yasuyoshi Watanabe², Katsunori Tanaka⁴.

Abstract

Multivalent interactions play an essential role in molecular recognition in living systems. These effects were employed to target tumor cells using albumin clusters bearing ∼10 molecules of asparagine-linked glycans (N-glycans). Noninvasive near-infrared fluorescence imaging clearly revealed A431 tumors implanted in BALB/cA-nu/nu mice after 1h in an N-glycan structure-dependent manner, thereby demonstrating the efficient use of glycan multivalency effects for tumor targeting in vivo.

Entities: Chemical Disease Species

Keywords: A431 tumor; In vivo molecular imaging; Multivalency effects; N-Glycan; α(2,3)-Disialoglycan

Mesh：

Substances：
Albumins
Polysaccharides

Year: 2016 PMID： 27020300 DOI： 10.1016/j.bmcl.2016.03.046

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

7 in total

Review 1. Homo- and Heterogeneous Glycoconjugates on the Basis of N-Glycans and Human Serum Albumin: Synthesis and Biological Evaluation.

Authors: Almira Kurbangalieva; Regina Zamalieva; Igor Nasibullin; Kenshiro Yamada; Katsunori Tanaka
Journal: Molecules Date: 2022-02-14 Impact factor: 4.411

2. A One-Pot Three-Component Double-Click Method for Synthesis of [⁶⁷Cu]-Labeled Biomolecular Radiotherapeutics.

Authors: Katsumasa Fujiki; Shinya Yano; Takeshi Ito; Yuki Kumagai; Yoshinori Murakami; Osamu Kamigaito; Hiromitsu Haba; Katsunori Tanaka
Journal: Sci Rep Date: 2017-05-15 Impact factor: 4.379

3. Sequential Double "Clicks" toward Structurally Well-Defined Heterogeneous N-Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo.

Authors: Liliya Latypova; Regina Sibgatullina; Akihiro Ogura; Katsumasa Fujiki; Alsu Khabibrakhmanova; Tsuyoshi Tahara; Satoshi Nozaki; Sayaka Urano; Kazuki Tsubokura; Hirotaka Onoe; Yasuyoshi Watanabe; Almira Kurbangalieva; Katsunori Tanaka
Journal: Adv Sci (Weinh) Date: 2016-11-28 Impact factor: 16.806

Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting.

Review 1. Homo- and Heterogeneous Glycoconjugates on the Basis of N-Glycans and Human Serum Albumin: Synthesis and Biological Evaluation.

2. A One-Pot Three-Component Double-Click Method for Synthesis of [⁶⁷Cu]-Labeled Biomolecular Radiotherapeutics.

3. Sequential Double "Clicks" toward Structurally Well-Defined Heterogeneous N-Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo.

Review 4. Unlocking the therapeutic potential of artificial metalloenzymes.

5. An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves.

6. Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy.

7. Synthetic prodrug design enables biocatalytic activation in mice to elicit tumor growth suppression.

Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting.

Review 1. Homo- and Heterogeneous Glycoconjugates on the Basis of N-Glycans and Human Serum Albumin: Synthesis and Biological Evaluation.

2. A One-Pot Three-Component Double-Click Method for Synthesis of [67Cu]-Labeled Biomolecular Radiotherapeutics.

3. Sequential Double "Clicks" toward Structurally Well-Defined Heterogeneous N-Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo.

Review 4. Unlocking the therapeutic potential of artificial metalloenzymes.

5. An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves.

6. Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy.

7. Synthetic prodrug design enables biocatalytic activation in mice to elicit tumor growth suppression.

2. A One-Pot Three-Component Double-Click Method for Synthesis of [⁶⁷Cu]-Labeled Biomolecular Radiotherapeutics.