Literature DB >> 27020267

Prognostic role of the combination of platelet count and neutrophil-lymphocyte ratio in patients with hypopharyngeal squamous cell carcinoma.

Mitsuhiko Nakahira1, Masashi Sugasawa2, Satoko Matsumura2, Kiyomi Kuba2, Susumu Ohba2, Takahiro Hayashi2, Kazuhiko Minami2, Yasuhiro Ebihara2, Yasunao Kogashiwa2.   

Abstract

Hypopharyngeal squamous cell carcinoma (HPSCC) is an aggressive disease with poor prognosis; but has no established biomarkers on the order of human papilloma virus and p16 in oropharyngeal carcinoma. This study investigated pre-treatment serum markers, including the combination of platelet count and neutrophil-lymphocyte ratio (COP-NLR) as a prognosis predictor in patients with HPSCC treated in our hospital. We retrospectively reviewed electronic medical records of 118 consecutive patients treated with curative intent at our hospital between 2007 and 2013. Of these 118 patients, we enrolled 100 patients for whom we had sufficient data to analyze relationships between clinico-laboratory characteristics and survival, including the prognostic significance of pre-treatment serum markers and previous reported clinical factors. Multivariate analysis of clinico-laboratory characteristics associated COP-NLR with cancer-specific survival, as were lymph node metastases. Kaplan-Meier analysis and log-rank tests showed that the COP-NLR could stratify those patients into three independent groups (P = 0.003). COP-NLR might be a useful predictor of survival in patients with HPSCC.

Entities:  

Keywords:  Biomarker; Hypopharyngeal cancer; Lymphocyte; Neutrophil; Platelet; Survival analysis

Mesh：

Year:  2016        PMID： 27020267     DOI： 10.1007/s00405-016-3996-3

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  22 in total

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Authors:  A Roboson
Journal:  Clin Otolaryngol Allied Sci       Date:  2002-10

Review 2.  Effects of cancer on platelets.

Authors:  Nick van Es; Auguste Sturk; Saskia Middeldorp; Rienk Nieuwland
Journal:  Semin Oncol       Date:  2014-04-24       Impact factor: 4.929

3.  HPV: a factor in organ preservation for locally advanced larynx and hypopharynx cancer?

Authors:  Joseph N Shaughnessy; Hanan Farghaly; Liz Wilson; Rebecca Redman; Kevin Potts; Jeffrey Bumpous; Craig Silverman; Neal E Dunlap
Journal:  Am J Otolaryngol       Date:  2013-10-09       Impact factor: 1.808

Review 4.  Platelets and cancer: implications for antiangiogenic therapy.

Authors:  Mohit Trikha; Marian T Nakada
Journal:  Semin Thromb Hemost       Date:  2002-02       Impact factor: 4.180

Review 5.  The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer.

Authors:  Graeme J K Guthrie; Kellie A Charles; Campbell S D Roxburgh; Paul G Horgan; Donald C McMillan; Stephen J Clarke
Journal:  Crit Rev Oncol Hematol       Date:  2013-04-17       Impact factor: 6.312

Review 6.  Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis.

Authors:  Camille C R Ragin; Emanuela Taioli
Journal:  Int J Cancer       Date:  2007-10-15       Impact factor: 7.396

7.  A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer.

Authors:  M J Proctor; D C McMillan; D S Morrison; C D Fletcher; P G Horgan; S J Clarke
Journal:  Br J Cancer       Date:  2012-07-24       Impact factor: 7.640

8.  Combination of platelet count and neutrophil to lymphocyte ratio is a useful predictor of postoperative survival in patients with colorectal cancer.

Authors:  M Ishizuka; H Nagata; K Takagi; Y Iwasaki; K Kubota
Journal:  Br J Cancer       Date:  2013-07-02       Impact factor: 7.640

9.  Lower circulating platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma.

Authors:  Saleh Rachidi; Kristin Wallace; Terry A Day; Anthony J Alberg; Zihai Li
Journal:  J Hematol Oncol       Date:  2014-09-27       Impact factor: 17.388

10.  Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer.

Authors:  G J K Guthrie; C S D Roxburgh; C H Richards; P G Horgan; D C McMillan
Journal:  Br J Cancer       Date:  2013-06-11       Impact factor: 7.640
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  8 in total

1.  Pretreatment neutrophil to lymphocyte ratio in determining the prognosis of head and neck cancer: a meta-analysis.

Authors:  Yalian Yu; Hongbo Wang; Aihui Yan; Hailong Wang; Xinyao Li; Jiangtao Liu; Wei Li
Journal:  BMC Cancer       Date:  2018-04-04       Impact factor: 4.430

2.  Sex Differences in Using Systemic Inflammatory Markers to Prognosticate Patients with Head and Neck Squamous Cell Carcinoma.

Authors:  Ching Ying Lin; Hyunwoo Kwon; Guillermo O Rangel Rivera; Xue Li; Dongjun Chung; Zihai Li
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2018-07-26       Impact factor: 4.254

3.  Pretreatment combination of platelet counts and neutrophil-lymphocyte ratio predicts survival of nasopharyngeal cancer patients receiving intensity-modulated radiotherapy.

Authors:  Yu-Hsuan Lin; Kuo-Ping Chang; Yaoh-Shiang Lin; Ting-Shou Chang
Journal:  Onco Targets Ther       Date:  2017-05-26       Impact factor: 4.147

4.  Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: a multi-institutional study in Japan.

Authors:  Daisuke Kawakita; Yuichiro Tada; Yorihisa Imanishi; Shintaro Beppu; Kiyoaki Tsukahara; Satoshi Kano; Hiroyuki Ozawa; Kenji Okami; Yuichiro Sato; Akira Shimizu; Yukiko Sato; Chihiro Fushimi; Soichiro Takase; Takuro Okada; Hiroki Sato; Kuninori Otsuka; Yoshihiro Watanabe; Akihiro Sakai; Koji Ebisumoto; Takafumi Togashi; Yushi Ueki; Hisayuki Ota; Tomotaka Shimura; Toyoyuki Hanazawa; Shingo Murakami; Toshitaka Nagao
Journal:  Oncotarget       Date:  2017-01-03

Review 5.  Cancer and Thrombosis: The Platelet Perspective.

Authors:  Claire K S Meikle; Clare A Kelly; Priyanka Garg; Leah M Wuescher; Ramadan A Ali; Randall G Worth
Journal:  Front Cell Dev Biol       Date:  2017-01-05

6.  The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma.

Authors:  Takuya Tsujino; Kazumasa Komura; Atsushi Ichihashi; Takeshi Tsutsumi; Tomohisa Matsunaga; Yuki Yoshikawa; Ryoichi Maenosono; Kyohei Okita; Tomoaki Takai; Rintaro Oide; Koichiro Minami; Hirofumi Uehara; Kohei Taniguchi; Hajime Hirano; Hayahito Nomi; Naokazu Ibuki; Kiyoshi Takahara; Teruo Inamoto; Haruhito Azuma
Journal:  Oncotarget       Date:  2017-11-25

7.  The Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Head and Neck Cancer Patients Treated with Radiotherapy.

Authors:  Yeona Cho; Jun Won Kim; Hong In Yoon; Chang Geol Lee; Ki Chang Keum; Ik Jae Lee
Journal:  J Clin Med       Date:  2018-12-03       Impact factor: 4.241

8.  High pretreatment neutrophil-to-lymphocyte ratio as a predictor of poor survival prognosis in head and neck squamous cell carcinoma: Systematic review and meta-analysis.

Authors:  Lin Yang; Yu Huang; Lie Zhou; Yuhong Dai; Guangyuan Hu
Journal:  Head Neck       Date:  2018-12-30       Impact factor: 3.147
  8 in total

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