Ji Young Kim1, Choae Lee1, Minsuk Oh1, Jee-Aee Im2, Ji-Won Lee3, Sang Hui Chu4, Hyangkyu Lee5, Justin Y Jeon6. 1. Department of Sport and Leisure Studies, Yonsei University, Seoul, Republic of Korea; Exercise Medicine Center for Cancer and Diabetes Patients, ICONS, Yonsei University, Seoul, Republic of Korea. 2. Sport and Medicine Research Center, INTOTO Inc., Seoul, Republic of Korea. 3. Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. 4. Department of Clinical Nursing Science, Yonsei University College of Nursing, Seoul, Republic of Korea; Nursing Policy and Research Institute, Biobehavioral Research Center, Yonsei University, Seoul, Republic of Korea. 5. Department of Clinical Nursing Science, Yonsei University College of Nursing, Seoul, Republic of Korea; Nursing Policy and Research Institute, Biobehavioral Research Center, Yonsei University, Seoul, Republic of Korea. Electronic address: hkyulee@yuhs.ac. 6. Department of Sport and Leisure Studies, Yonsei University, Seoul, Republic of Korea; Exercise Medicine Center for Cancer and Diabetes Patients, ICONS, Yonsei University, Seoul, Republic of Korea. Electronic address: jjeon@yonsei.ac.kr.
Abstract
BACKGROUND: We investigated the independent and combined impact of obesity and nonalcoholic fatty liver disease (NAFLD) on components and prevalence of metabolic syndrome in Korean adults. METHODS: This study included 1695 adults (500 males and 1,195 females), who took part in a regular health check-up at the community-based health promotion center. Participants were divided according to degree of adiposity and the presence of NAFLD. The components and prevalence of metabolic syndrome were compared. RESULTS: Fasting glucose was significantly higher in nonobese participants with NAFLD compared to obese participants without NAFLD. Logistic regression analysis revealed that the presence of NAFLD was associated with 3.63 times increased prevalence of metabolic syndrome (95% CI: 1.21-10.86) while obesity without NAFLD was associated with 3.84 times increased prevalence of metabolic syndrome (95% CI: 1.57-9.36) in male. In female, the presence of NAFLD was associated with 5.56 times higher prevalence of metabolic syndrome (95% CI: 2.53-12.23) while obesity without NAFLD had 3.46 times increased prevalence of metabolic syndrome (95% CI: 1.64-7.33). CONCLUSIONS: NAFLD is associated with the prevalence of metabolic syndrome, independent of adiposity. In females, NAFLD may be a more important factor than obesity for risk of metabolic syndrome.
BACKGROUND: We investigated the independent and combined impact of obesity and nonalcoholic fatty liver disease (NAFLD) on components and prevalence of metabolic syndrome in Korean adults. METHODS: This study included 1695 adults (500 males and 1,195 females), who took part in a regular health check-up at the community-based health promotion center. Participants were divided according to degree of adiposity and the presence of NAFLD. The components and prevalence of metabolic syndrome were compared. RESULTS: Fasting glucose was significantly higher in nonobese participants with NAFLD compared to obeseparticipants without NAFLD. Logistic regression analysis revealed that the presence of NAFLD was associated with 3.63 times increased prevalence of metabolic syndrome (95% CI: 1.21-10.86) while obesity without NAFLD was associated with 3.84 times increased prevalence of metabolic syndrome (95% CI: 1.57-9.36) in male. In female, the presence of NAFLD was associated with 5.56 times higher prevalence of metabolic syndrome (95% CI: 2.53-12.23) while obesity without NAFLD had 3.46 times increased prevalence of metabolic syndrome (95% CI: 1.64-7.33). CONCLUSIONS: NAFLD is associated with the prevalence of metabolic syndrome, independent of adiposity. In females, NAFLD may be a more important factor than obesity for risk of metabolic syndrome.