Karen S van den Berg1, Radboud M Marijnissen2, Rob H S van den Brink3, Paul Naarding4, Hannie C Comijs5, Richard C Oude Voshaar3. 1. University Medical Center Groningen, University Center of Psychiatry, University of Groningen, Groningen, The Netherlands; Department of Old Age Psychiatry, Pro Persona, Wolfheze, The Netherlands. Electronic address: k.s.van.den.berg@umcg.nl. 2. University Medical Center Groningen, University Center of Psychiatry, University of Groningen, Groningen, The Netherlands; Department of Old Age Psychiatry, Pro Persona, Wolfheze, The Netherlands. 3. University Medical Center Groningen, University Center of Psychiatry, University of Groningen, Groningen, The Netherlands. 4. GGNet, Center for Old Age Psychiatry, Apeldoorn, The Netherlands. 5. Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center/GGZinGeest, Amsterdam, The Netherlands.
Abstract
OBJECTIVE: To study the effect of vitamin D levels on depression course and remission status after two years, as well as attrition and mortality, in an older cohort. METHODS: This study was part of the Netherlands Study on Depression in Older persons (NESDO), a prospective cohort study. 367 depressed older persons (≥ 60 years) were included. Baseline vitamin D status, reasons for loss to follow up, clinical depression diagnosis at two-year follow up, and six-monthly symptom scores were obtained. Data were analyzed by logistic regression and random coefficient models and adjusted for confounders of vitamin D status. RESULTS: Vitamin D had no effect on the course of depression or remission, except for a trend towards lower remission rates in the severely deficient subgroup (25-(OH) vitamin D<25 nmol/l). Patients who died during follow up had significantly lower 25-(OH) vitamin D and 1,25-(OH)2 vitamin D levels than patients with continued participation. CONCLUSIONS: For the total sample we found no effect of vitamin D levels on the course of depression or remission rates. However, we did find an effect of lower vitamin D levels on mortality. This strengthens the interpretation of vitamin D deficiency being a marker for poor somatic health status. The trend towards lower remission rates in the severely deficient subgroup raises the question whether this group could benefit from supplementation. Randomized controlled trials are necessary to study this.
OBJECTIVE: To study the effect of vitamin D levels on depression course and remission status after two years, as well as attrition and mortality, in an older cohort. METHODS: This study was part of the Netherlands Study on Depression in Older persons (NESDO), a prospective cohort study. 367 depressed older persons (≥ 60 years) were included. Baseline vitamin D status, reasons for loss to follow up, clinical depression diagnosis at two-year follow up, and six-monthly symptom scores were obtained. Data were analyzed by logistic regression and random coefficient models and adjusted for confounders of vitamin D status. RESULTS:Vitamin D had no effect on the course of depression or remission, except for a trend towards lower remission rates in the severely deficient subgroup (25-(OH) vitamin D<25 nmol/l). Patients who died during follow up had significantly lower 25-(OH) vitamin D and 1,25-(OH)2 vitamin D levels than patients with continued participation. CONCLUSIONS: For the total sample we found no effect of vitamin D levels on the course of depression or remission rates. However, we did find an effect of lower vitamin D levels on mortality. This strengthens the interpretation of vitamin D deficiency being a marker for poor somatic health status. The trend towards lower remission rates in the severely deficient subgroup raises the question whether this group could benefit from supplementation. Randomized controlled trials are necessary to study this.
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