| Literature DB >> 2701942 |
N Tomita1, A Horii, S Doi, H Yokouchi, K Shiosaki, M Higashiyama, N Matsuura, M Ogawa, T Mori, K Matsubara.
Abstract
A novel type of alpha-amylase was detected in a lung carcinoid tissue after surveying the cDNA library constructed from this tumor mRNA. Nucleotide sequence analysis showed that the amylase expressed in this carcinoid tumor has 13 and 6 amino acid substitutions when compared with salivary amylase (Amy1) and pancreatic amylase (Amy2), respectively. The nucleotide sequence homologies of cDNAs between this carcinoid amylase and amy1, amy2 are 97.5% and 98.2%, respectively. The nucleotide sequence comparison strongly suggests that this new amylase is the product of the amy3 gene that has been detected in human genome [Emi et al., Gene 62 (1988) 229-235]Entities:
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Year: 1989 PMID： 2701942 DOI： 10.1016/0378-1119(89)90003-6
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688