Lisa M Moran1, Talin Babikian1, Larissa Del Piero2, Monica U Ellis1, Claudia L Kernan1, Nina Newman1, Christopher C Giza3, Richard Mink4, Jeffrey Johnson5, Christopher Babbitt6, Robert Asarnow1. 1. 1Department of Psychiatry and Biobehavioral Health,University of California,Los Angeles,California. 2. 3Department of Psychology,University of Southern California,Los Angeles,California. 3. 2Department of Pediatrics, University of California,Los Angeles,California. 4. 7Department of Pediatrics,Los Angeles County & Harbor University of California,Los Angeles,California. 5. 8Department of Pediatrics,Los Angeles County & University of Southern California Medical Center,Los Angeles,California. 6. 9Department of Pediatrics,Miller Children's Hospital,Long Beach,California.
Abstract
OBJECTIVES: Following pediatric moderate-to-severe traumatic brain injury (msTBI), few predictors have been identified that can reliably identify which individuals are at risk for long-term cognitive difficulties. This study sought to determine the relative contribution of detailed descriptors of injury severity as well as demographic and psychosocial factors to long-term cognitive outcomes after pediatric msTBI. METHODS: Participants included 8- to 19-year-olds, 46 with msTBI and 53 uninjured healthy controls (HC). Assessments were conducted in the post-acute and chronic stages of recovery. Medical record review provided details regarding acute injury severity. Parents also completed a measure of premorbid functioning and behavioral problems. The outcome of interest was four neurocognitive measures sensitive to msTBI combined to create an index of cognitive performance. RESULTS: Results indicated that none of the detailed descriptors of acute injury severity predicted cognitive performance. Only the occurrence of injury, parental education, and premorbid academic competence predicted post-acute cognitive functioning. Long-term cognitive outcomes were best predicted by post-acute cognitive functioning. DISCUSSION: The findings suggest that premorbid factors influence cognitive outcomes nearly as much as the occurrence of a msTBI. Furthermore, of youth with msTBI who initially recover to a level of moderate disability or better, a brief cognitive battery administered within several months after injury can best predict which individuals will experience poor long-term cognitive outcomes and require additional services.
OBJECTIVES: Following pediatric moderate-to-severe traumatic brain injury (msTBI), few predictors have been identified that can reliably identify which individuals are at risk for long-term cognitive difficulties. This study sought to determine the relative contribution of detailed descriptors of injury severity as well as demographic and psychosocial factors to long-term cognitive outcomes after pediatric msTBI. METHODS:Participants included 8- to 19-year-olds, 46 with msTBI and 53 uninjured healthy controls (HC). Assessments were conducted in the post-acute and chronic stages of recovery. Medical record review provided details regarding acute injury severity. Parents also completed a measure of premorbid functioning and behavioral problems. The outcome of interest was four neurocognitive measures sensitive to msTBI combined to create an index of cognitive performance. RESULTS: Results indicated that none of the detailed descriptors of acute injury severity predicted cognitive performance. Only the occurrence of injury, parental education, and premorbid academic competence predicted post-acute cognitive functioning. Long-term cognitive outcomes were best predicted by post-acute cognitive functioning. DISCUSSION: The findings suggest that premorbid factors influence cognitive outcomes nearly as much as the occurrence of a msTBI. Furthermore, of youth with msTBI who initially recover to a level of moderate disability or better, a brief cognitive battery administered within several months after injury can best predict which individuals will experience poor long-term cognitive outcomes and require additional services.
Authors: Emily L Dennis; Talin Babikian; Christopher C Giza; Paul M Thompson; Robert F Asarnow Journal: Neuroscientist Date: 2018-02-28 Impact factor: 7.519
Authors: Talin Babikian; Jeffry R Alger; Monica U Ellis-Blied; Christopher C Giza; Emily Dennis; Alexander Olsen; Richard Mink; Christopher Babbitt; Jeff Johnson; Paul M Thompson; Robert F Asarnow Journal: J Neurotrauma Date: 2018-05-18 Impact factor: 5.269
Authors: Emily L Dennis; Talin Babikian; Jeffry Alger; Faisal Rashid; Julio E Villalon-Reina; Yan Jin; Alexander Olsen; Richard Mink; Christopher Babbitt; Jeffrey Johnson; Christopher C Giza; Paul M Thompson; Robert F Asarnow Journal: Hum Brain Mapp Date: 2018-05-10 Impact factor: 5.038
Authors: Emily L Dennis; Faisal Rashid; Monica U Ellis; Talin Babikian; Roza M Vlasova; Julio E Villalon-Reina; Yan Jin; Alexander Olsen; Richard Mink; Christopher Babbitt; Jeffrey Johnson; Christopher C Giza; Paul M Thompson; Robert F Asarnow Journal: Neurology Date: 2017-03-15 Impact factor: 9.910
Authors: Emily L Dennis; Joshua Faskowitz; Faisal Rashid; Talin Babikian; Richard Mink; Christopher Babbitt; Jeffrey Johnson; Christopher C Giza; Neda Jahanshad; Paul M Thompson; Robert F Asarnow Journal: Neuroimage Clin Date: 2017-03-31 Impact factor: 4.881
Authors: Alexander Olsen; Talin Babikian; Emily L Dennis; Monica U Ellis-Blied; Christopher Giza; Sarah DeBoard Marion; Richard Mink; Jeffrey Johnson; Christopher J Babbitt; Paul M Thompson; Robert F Asarnow Journal: J Neurotrauma Date: 2019-09-25 Impact factor: 5.269
Authors: Ajit Sarnaik; Nikki Miller Ferguson; A M Iqbal O'Meara; Shruti Agrawal; Akash Deep; Sandra Buttram; Michael J Bell; Stephen R Wisniewski; James F Luther; Adam L Hartman; Monica S Vavilala Journal: Neurocrit Care Date: 2018-06 Impact factor: 3.210
Authors: Sean Wei Yi Lee; Yang Ming; Swati Jain; Shu Ying Chee; Kejia Teo; Ning Chou; Sein Lwin; Tseng Tsai Yeo; Vincent Diong Weng Nga Journal: Asian J Neurosurg Date: 2019 Jul-Sep