| Literature DB >> 27019112 |
Hui Zhang1, Wenjuan Pu1, Xueying Tian1, Xiuzhen Huang1, Lingjuan He1, Qiaozhen Liu1, Yan Li1, Libo Zhang1, Liang He1, Kuo Liu1,2, Astrid Gillich3, Bin Zhou1,2,4.
Abstract
The hepatic vasculature is essential for liver development, homeostasis and regeneration, yet the developmental program of hepatic vessel formation and the embryonic origin of the liver vasculature remain unknown. Here we show in mouse that endocardial cells form a primitive vascular plexus surrounding the liver bud and subsequently contribute to a substantial portion of the liver vasculature. Using intersectional genetics, we demonstrate that the endocardium of the sinus venosus is a source for the hepatic plexus. Inhibition of endocardial angiogenesis results in reduced endocardial contribution to the liver vasculature and defects in liver organogenesis. We conclude that a substantial portion of liver vessels derives from the endocardium and shares a common developmental origin with coronary arteries.Entities:
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Year: 2016 PMID： 27019112 DOI： 10.1038/ng.3536
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330