Literature DB >> 27019029

Automated synthesis of [(18)F](2S,4R)-4-fluoroglutamine on a GE TRACERlab™ FX-N Pro module.

Xiang Zhang1, Falguni Basuli1, Zhen-Dan Shi1, Biying Xu1, Burchelle Blackman1, Peter L Choyke2, Rolf E Swenson3.   

Abstract

Glutamine (Gln) and its analogues may serve as imaging agents for tumor diagnosis using positron emission tomography (PET), especially for tumors with negative [(18)F]FDG scan. We report the first automated synthesis of [(18)F](2S,4R)-4-fluoroglutamine ([(18)F]FGln) on a GE TRACERlab™ FX-N Pro module. [(18)F]FGln was obtained in 80±3min with a radiochemical yield of 21±3% (n=5, uncorrected). The radiochemical purity was >98%, and optical purity 90±5%. The synthesis is highly reproducible with good chemical purity, radiochemical yield, and is suitable for translation to cGMP production.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Keywords:  Automation; F-18; Fluoroglutamine; PET imaging; Tumor

Mesh：

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Year:  2016        PMID： 27019029      PMCID： PMC4853275          DOI： 10.1016/j.apradiso.2016.02.016

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  10 in total

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3.  Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression.

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  3 in total

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