Literature DB >> 27018282

The role of calsyntenin-3 in dystrophic neurite formation in Alzheimer's disease brain.

Yoko Uchida1, Fujiya Gomi1.   

Abstract

β-Amyloid (Aβ) oligomers may play an important role in the early pathogenesis of Alzheimer's disease: cognitive impairment caused by synaptic dysfunction. Dystrophic neurites surrounding Aβ plaques, another pathological feature of Alzheimer's disease, are plaque-associated neuritic alterations preceding the appearance of synaptic loss. In the present review, we focus on the mechanism of dystrophic neurite formation by Aß oligomers, and discuss the neurotoxic role of Aβ-induced calsyntenin-3 in mediating dystrophic neurite formation.
© 2016 Japan Geriatrics Society.

Entities:  

Keywords:  Alzheimer's disease; calsyntenin-3; dystrophic neurites; neurotoxicity; β-amyloid

Mesh：

Substances：

Year:  2016        PMID： 27018282     DOI： 10.1111/ggi.12737

Source DB:  PubMed          Journal:  Geriatr Gerontol Int        ISSN： 1447-0594            Impact factor:   2.730


  3 in total

1.  Perinatal Lead Exposure Alters Calsyntenin-2 and Calsyntenin-3 Expression in the Hippocampus and Causes Learning Deficits in Mice Post-weaning.

Authors:  Ning Li; Shuai Cao; Zengli Yu; Mingwu Qiao; Yongxia Cheng; Yue Shen; Lianjun Song; Xianqing Huang; Guojun Yang; Yali Zhao
Journal:  Biol Trace Elem Res       Date:  2020-06-16       Impact factor: 3.738

2.  Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria.

Authors:  Chen Ding; Youjun Wu; Hadas Dabas; Marc Hammarlund
Journal:  Elife       Date:  2022-03-14       Impact factor: 8.140

Review 3.  3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish".

Authors:  Se Hoon Choi; Young Hye Kim; Luisa Quinti; Rudolph E Tanzi; Doo Yeon Kim
Journal:  Mol Neurodegener       Date:  2016-12-09       Impact factor: 14.195
  3 in total

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