Yanna Dou1,2, Li Zhang1,2, Dong Liu3,4, Chunyan Wang1,2,5, Songxia Quan1,2,5, Shuang Ma1,2, Jing Xiao1,2, Genyang Cheng1,2, Zhangsuo Liu1,2, Zhanzheng Zhao6,7. 1. The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Eastern Road, 6th Floor of No. 7th Building, Erqi District, Zhengzhou, 450052, Henan, China. 2. Zhengzhou University Institute of Nephrology, Zhengzhou, China. 3. The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Eastern Road, 6th Floor of No. 7th Building, Erqi District, Zhengzhou, 450052, Henan, China. liudong030@163.com. 4. Zhengzhou University Institute of Nephrology, Zhengzhou, China. liudong030@163.com. 5. The Key Laboratory of CKD and Renal Pathology of Henan Province, Zhengzhou, China. 6. The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Eastern Road, 6th Floor of No. 7th Building, Erqi District, Zhengzhou, 450052, Henan, China. zzzdoctor@139.com. 7. Zhengzhou University Institute of Nephrology, Zhengzhou, China. zzzdoctor@139.com.
Abstract
AIM: Recent studies have revealed that anti-phospholipase A2 receptor antibodies (aPLA2R-ABs) may play a role in the diagnosis of idiopathic membranous nephropathy (IMN). We will investigate the application of an aPLA2R-AB with different cutoff values for diagnosing IMN. METHODS: From August 2014 to December 2014, patients with proteinuria greater than 1 g/day were screened at the First Affiliated Hospital of Zhengzhou University. Patients were divided into the IMN and non-IMN groups based on the results of renal biopsy. The sensitivity, specificity, and receiver operating characteristic (ROC) curve of aPLA2R-AB for diagnosing IMN were analyzed. RESULTS: A total of 229 patients (113 males, average age of 45.3 ± 15.8 years) were enrolled in this study, and 118 patients were diagnosed with IMN. The sensitivity/specificity of aPLA2R-AB in the diagnosis of IMN was 65.3/97.3 %, 60.2/97.3 %, and 45.8/97.3 % for the different cutoff values (14, 20, and 40 RU/ml). The area of the ROC curve was 0.87. CONCLUSION: Anti-PLA2R-AB with a cutoff value of 14 RU/ml based on the ELISA method plays an important role in the diagnosis of IMN.
AIM: Recent studies have revealed that anti-phospholipase A2 receptor antibodies (aPLA2R-ABs) may play a role in the diagnosis of idiopathic membranous nephropathy (IMN). We will investigate the application of an aPLA2R-AB with different cutoff values for diagnosing IMN. METHODS: From August 2014 to December 2014, patients with proteinuria greater than 1 g/day were screened at the First Affiliated Hospital of Zhengzhou University. Patients were divided into the IMN and non-IMN groups based on the results of renal biopsy. The sensitivity, specificity, and receiver operating characteristic (ROC) curve of aPLA2R-AB for diagnosing IMN were analyzed. RESULTS: A total of 229 patients (113 males, average age of 45.3 ± 15.8 years) were enrolled in this study, and 118 patients were diagnosed with IMN. The sensitivity/specificity of aPLA2R-AB in the diagnosis of IMN was 65.3/97.3 %, 60.2/97.3 %, and 45.8/97.3 % for the different cutoff values (14, 20, and 40 RU/ml). The area of the ROC curve was 0.87. CONCLUSION: Anti-PLA2R-AB with a cutoff value of 14 RU/ml based on the ELISA method plays an important role in the diagnosis of IMN.
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