Literature DB >> 27017330

HOPX: The Unusual Homeodomain-Containing Protein.

Anita Mariotto1, Olesya Pavlova1, Hyun-Sook Park1, Marcel Huber1, Daniel Hohl2.   

Abstract

The homeodomain-only protein homeobox (HOPX) is the smallest known member of the homeodomain-containing protein family, atypically unable to bind DNA. HOPX is widely expressed in diverse tissues, where it is critically involved in the regulation of proliferation and differentiation. In human skin, HOPX controls epidermal formation through the regulation of late differentiation markers, and HOPX expression correlates with the level of differentiation in cutaneous pathologies. In mouse skin, Hopx was additionally identified as a lineage tracing marker of quiescent hair follicle stem cells. This review discusses current knowledge of HOPX structure and function in normal and pathological conditions.
Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27017330     DOI： 10.1016/j.jid.2016.01.032

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  17 in total

1.  Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis.

Authors:  Christian F Guerrero-Juarez; Aliaksandr A Astrowski; Rabi Murad; Christina T Dang; Vera O Shatrova; Aksana Astrowskaja; Chae Ho Lim; Raul Ramos; Xiaojie Wang; Yuchen Liu; Hye-Lim Lee; Kim T Pham; Tsai-Ching Hsi; Ji Won Oh; Daniel Crocker; Ali Mortazavi; Mayumi Ito; Maksim V Plikus
Journal:  J Invest Dermatol       Date:  2018-01-06       Impact factor: 8.551

Review 2.  The role of miRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults.

Authors:  Mitchell C Lock; Ross L Tellam; Kimberley J Botting; Kimberley C W Wang; Joseph B Selvanayagam; Doug A Brooks; Mike Seed; Janna L Morrison
Journal:  J Physiol       Date:  2018-06-28       Impact factor: 5.182

3.  HOPX Is a ZNF750 Target that Promotes Late Epidermal Differentiation.

Authors:  Selena Y Chen; Mitsuhiro A Ishii; Binbin Cheng; Auke B C Otten; Bryan K Sun
Journal:  J Invest Dermatol       Date:  2019-04-05       Impact factor: 8.551

Review 4.  Transcriptional Regulators and Human-Specific/Primate-Specific Genes in Neocortical Neurogenesis.

Authors:  Samir Vaid; Wieland B Huttner
Journal:  Int J Mol Sci       Date:  2020-06-29       Impact factor: 5.923

5.  HOPX homeobox methylation in differentiated thyroid cancer and its clinical relevance.

Authors:  Erika Urbano Lima; Ileana G S Rubio; Joaquim Custodio Da Silva; Ana Luiza Galrão; Danielle Pêssoa; Taise Cerqueira Oliveira; Fabiane Carrijo; Igor Silva Campos; Luciano Fonseca Espinheira; Luiz Jose Sampaio; Claudio Rogerio Lima; Janete Maria Cerutti; Helton Estrela Ramos
Journal:  Endocr Connect       Date:  2018-12       Impact factor: 3.335

6.  Regional methylome profiling reveals dynamic epigenetic heterogeneity and convergent hypomethylation of stem cell quiescence-associated genes in breast cancer following neoadjuvant chemotherapy.

Authors:  Yumei Luo; Juan Huang; Yi Tang; Xitu Luo; Lingxia Ge; Xiujie Sheng; Xiaofang Sun; Yaoyong Chen; Detu Zhu
Journal:  Cell Biosci       Date:  2019-02-07       Impact factor: 7.133

7.  YAP1/TAZ drives ependymoma-like tumour formation in mice.

Authors:  Noreen Eder; Federico Roncaroli; Marie-Charlotte Domart; Stuart Horswell; Felipe Andreiuolo; Helen R Flynn; Andre T Lopes; Suzanne Claxton; John-Paul Kilday; Lucy Collinson; Jun-Hao Mao; Torsten Pietsch; Barry Thompson; Ambrosius P Snijders; Sila K Ultanir
Journal:  Nat Commun       Date:  2020-05-13       Impact factor: 14.919

8.  HOPX functions as a tumour suppressor in head and neck cancer.

Authors:  Lee Fah Yap; Sook Ling Lai; Sathya Narayanan Patmanathan; Ravindran Gokulan; C Max Robinson; Joe B White; San Jiun Chai; Pathmanathan Rajadurai; Narayanan Prepageran; Yew Toong Liew; Victor Lopes; Wenbin Wei; Robert J Hollows; Paul G Murray; Daniel W Lambert; Keith D Hunter; Ian C Paterson
Journal:  Sci Rep       Date:  2016-12-09       Impact factor: 4.379

9.  KLF3 Mediates Epidermal Differentiation through the Epigenomic Writer CBP.

Authors:  Jackson Jones; Yifang Chen; Manisha Tiwari; Jingting Li; Ji Ling; George L Sen
Journal:  iScience       Date:  2020-06-29

10.  Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease.

Authors:  Peter A Szabo; Hanna Mendes Levitin; Michelle Miron; Mark E Snyder; Takashi Senda; Jinzhou Yuan; Yim Ling Cheng; Erin C Bush; Pranay Dogra; Puspa Thapa; Donna L Farber; Peter A Sims
Journal:  Nat Commun       Date:  2019-10-17       Impact factor: 14.919
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