Literature DB >> 27017109

Paternity testing that involves a DNA mixture.

Julia Mortera1, Carla Vecchiotti2, Silvia Zoppis2, Sara Merigioli3.   

Abstract

Here we analyse a complex disputed paternity case, where the DNA of the putative father was extracted from his corpse that had been inhumed for over 20 years. This DNA was contaminated and appears to be a mixture of at least two individuals. Furthermore, the mother's DNA was not available. The DNA mixture was analysed so as to predict the most probable genotypes of each contributor. The major contributor's profile was then used to compute the likelihood ratio for paternity. We also show how to take into account a dropout allele and the possibility of mutation in paternity testing.
Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Keywords:  DNA mixtures; Deconvolution; Disputed paternity; Dropout allele; Likelihood ratio; Mutation

Mesh:

Substances:

Year:  2016        PMID: 27017109     DOI: 10.1016/j.fsigen.2016.02.014

Source DB:  PubMed          Journal:  Forensic Sci Int Genet        ISSN: 1872-4973            Impact factor:   4.882


  1 in total

1.  Pedigree-based relationship inference from complex DNA mixtures.

Authors:  Guro Dørum; Navreet Kaur; Mario Gysi
Journal:  Int J Legal Med       Date:  2017-01-19       Impact factor: 2.686

  1 in total

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