Ya Xing Wang1, Ran Jiang1, Xiao Lei Ren1, Jian Dong Chen1, Hong Li Shi2, Liang Xu1, Wen Bin Wei3, Jost B Jonas1,4. 1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China. 2. College of Biomedical Engineering, Capital Medical University, Beijing, China. 3. Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 4. Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Seegartenklinik Heidelberg, Germany.
Abstract
PURPOSE: To evaluate changes in subfoveal choroidal thickness (SFCT) and peripapillary choroidal thickness (PPCT) after acute intraocular pressure (IOP) elevation provoked by a dark room prone provocative test (DRPPT). METHODS: The prospective cohort study included 114 eyes from 65 individuals who had an IOP elevation ≥2 mm Hg during the DRPPT. The participants stayed in a dark room for 2 h with the forehead placed on a desk. At baseline and within 5 min after the end of the DRPPT, tonometry and enhanced depth imaging by spectral-domain optical coherence tomography were carried out. RESULTS: During the DRPPT, IOP increased by 10.1±10.9 mm Hg, SFCT decreased significantly (p<0.001) from 280±80 µm to 267±76 µm and PPCT decreased significantly (p<0.001) from 177±74 to 169±70 µm. In multivariate analysis, a more marked SFCT thinning was associated with higher IOP increase (p<0.001) and shallower anterior chamber depth at baseline (p=0.01). In a similar manner, a higher PPCT change was correlated with a higher IOP increase (p<0.001), and a thicker choroidal thickness at baseline (p<0.001). CONCLUSIONS: Choroidal thickness in the subfoveal region and in the peripapillary region decreased parallel to an acute increase in IOP in individuals 2 h after a dark room test. Choroidal thickness depends on the actual IOP, which may be noted when choroidal thickness is measured. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
PURPOSE: To evaluate changes in subfoveal choroidal thickness (SFCT) and peripapillary choroidal thickness (PPCT) after acute intraocular pressure (IOP) elevation provoked by a dark room prone provocative test (DRPPT). METHODS: The prospective cohort study included 114 eyes from 65 individuals who had an IOP elevation ≥2 mm Hg during the DRPPT. The participants stayed in a dark room for 2 h with the forehead placed on a desk. At baseline and within 5 min after the end of the DRPPT, tonometry and enhanced depth imaging by spectral-domain optical coherence tomography were carried out. RESULTS: During the DRPPT, IOP increased by 10.1±10.9 mm Hg, SFCT decreased significantly (p<0.001) from 280±80 µm to 267±76 µm and PPCT decreased significantly (p<0.001) from 177±74 to 169±70 µm. In multivariate analysis, a more marked SFCT thinning was associated with higher IOP increase (p<0.001) and shallower anterior chamber depth at baseline (p=0.01). In a similar manner, a higher PPCT change was correlated with a higher IOP increase (p<0.001), and a thicker choroidal thickness at baseline (p<0.001). CONCLUSIONS: Choroidal thickness in the subfoveal region and in the peripapillary region decreased parallel to an acute increase in IOP in individuals 2 h after a dark room test. Choroidal thickness depends on the actual IOP, which may be noted when choroidal thickness is measured. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
Authors: Dan Zhu; Yan Wang; Yan Fei Zheng; Da Yong Yang; Kai Guo; Xian Rong Yang; Xin Xia Jing; Ian Y Wong; Qi Sheng You; Yong Tao; Jost B Jonas Journal: PLoS One Date: 2017-06-15 Impact factor: 3.240