Mohammad Talal Elhakim1, Helle Breinholt1, Christian Godballe1, Lisbeth Juhler Andersen2, Hanne Primdahl3, Claus A Kristensen4, Kristine Bjørndal5. 1. Department of ORL - Head and Neck Surgery, Odense University Hospital, Denmark. 2. Department of Oncology, Aalborg University Hospital, Denmark. 3. Department of Oncology, Aarhus University Hospital, Denmark. 4. Department of Oncology, Copenhagen University Hospital/Rigshospitalet, Denmark. 5. Department of ORL - Head and Neck Surgery, Odense University Hospital, Denmark. Electronic address: Kristine.Bjoerndal@rsyd.dk.
Abstract
OBJECTIVES: To present a national series of polymorphous low-grade adenocarcinoma (PLGA) patients, including survival rates and an analysis of prognostic factors. MATERIALS AND METHODS: By merging three Danish nationwide registries, 73 patients diagnosed with PLGA from 1990 to 2005 were identified. Histological slides were reviewed and data concerning demographics, tumour site, clinical stage, treatment profiles and follow-up were retrieved. Survival estimates and prognostic factors were evaluated by comparing Kaplan-Meier plots using the Mantel-Haenszel log-rank test. RESULTS: Of the 73 patients, 47 (64%) were female. Median age was 58years. The most common location was the palate (73%). Median latency was five months. Recurrence was seen in 13% of patients. Overall survival (OS), disease-specific survival (DSS) and recurrence-free survival (RFS) rates after 10years were 73%, 99% and 83%, respectively. Univariate analyses suggested that free resection margins significantly improve RFS. CONCLUSION: PLGA usually has an excellent survival outcome even in cases of advanced stage disease and locoregional recurrence. Primary choice of treatment should be complete surgical excision. Although there is no convincing evidence for the efficacy of adjuvant radiotherapy, it should still be considered, particularly in cases of involved resection margins and advanced stage disease. Late recurrences are common and respond well to salvage therapy.
OBJECTIVES: To present a national series of polymorphous low-grade adenocarcinoma (PLGA) patients, including survival rates and an analysis of prognostic factors. MATERIALS AND METHODS: By merging three Danish nationwide registries, 73 patients diagnosed with PLGA from 1990 to 2005 were identified. Histological slides were reviewed and data concerning demographics, tumour site, clinical stage, treatment profiles and follow-up were retrieved. Survival estimates and prognostic factors were evaluated by comparing Kaplan-Meier plots using the Mantel-Haenszel log-rank test. RESULTS: Of the 73 patients, 47 (64%) were female. Median age was 58years. The most common location was the palate (73%). Median latency was five months. Recurrence was seen in 13% of patients. Overall survival (OS), disease-specific survival (DSS) and recurrence-free survival (RFS) rates after 10years were 73%, 99% and 83%, respectively. Univariate analyses suggested that free resection margins significantly improve RFS. CONCLUSION: PLGA usually has an excellent survival outcome even in cases of advanced stage disease and locoregional recurrence. Primary choice of treatment should be complete surgical excision. Although there is no convincing evidence for the efficacy of adjuvant radiotherapy, it should still be considered, particularly in cases of involved resection margins and advanced stage disease. Late recurrences are common and respond well to salvage therapy.
Authors: Ximena Mimica; Nora Katabi; Marlena R McGill; Ashley Hay; Daniella Karassawa Zanoni; Jatin P Shah; Richard J Wong; Marc A Cohen; Snehal G Patel; Ian Ganly Journal: Oral Oncol Date: 2019-06-07 Impact factor: 5.337
Authors: Bin Xu; Ronald Ghossein; Alan Ho; Kartik Viswanathan; Anjanie Khimraj; Maelle Saliba; Jennifer R Cracchiolo; Nora Katabi Journal: Head Neck Date: 2021-04-24 Impact factor: 3.821