Literature DB >> 2701569

19F MRS studies of fluoropyrimidine chemotherapy. A review.

P M McSheehy1, J R Griffiths.   

Abstract

19F NMR spectroscopy (MRS) has been used to follow the metabolism of the fluoropyrimidine anticancer drug 5-fluorouracil and its derivatives non-invasively, both in animals and humans. This review is concerned with the information that has been acquired concerning cytotoxicity and detoxification in relation to studies performed with conventional methods. The potential uses of 19F MRS of fluoropyrimidines in research, particularly concerning combination chemotherapy, and in monitoring therapy, are discussed.

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Year:  1989        PMID： 2701569     DOI： 10.1002/nbm.1940020402

Source DB:  PubMed          Journal:  NMR Biomed        ISSN： 0952-3480            Impact factor:   4.044


  8 in total

Review 1.  Do anticancer agents reach the tumor target in the human brain?

Authors:  M G Donelli; M Zucchetti; M D'Incalci
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 2.  Uses and limitations of nuclear magnetic resonance (NMR) spectroscopy in clinical pharmacokinetics.

Authors:  M C Malet-Martino; R Martino
Journal:  Clin Pharmacokinet       Date:  1991-05       Impact factor: 6.447

Review 3.  Functional MRI and CT biomarkers in oncology.

Authors:  J M Winfield; G S Payne; N M deSouza
Journal:  Eur J Nucl Med Mol Imaging       Date:  2015-01-13       Impact factor: 9.236

4.  Influence of 5-fluorouracil-loaded microsphere formulation on efficient rat glioma radiosensitization.

Authors:  Valérie-Gaëlle Roullin; Martine Mege; Laurent Lemaire; Jean-Pierre Cueyssac; Marie-Claire Venier-Julienne; Philippe Menei; Erik Gamelin; Jean-Pierre Benoit
Journal:  Pharm Res       Date:  2004-09       Impact factor: 4.200

5.  Locoregional administration of 5-fluoro-2'-deoxyuridine (FdUrd) in Novikoff hepatoma in the rat: effects of dose and infusion time on tumor growth and on FdUrd metabolite levels in tumor tissue as determined by 19F-NMR spectroscopy.

Authors:  B Naser-Hijazi; M R Berger; D Schmähl; P Schlag; W E Hull
Journal:  J Cancer Res Clin Oncol       Date:  1991       Impact factor: 4.553

6.  Enhanced 5-fluorouracil cytotoxicity and elevated 5-fluoronucleotides in the rat Walker carcinosarcoma following methotrexate pre-treatment: a 19F-MRS study in vivo.

Authors:  P M McSheehy; M J Prior; J R Griffiths
Journal:  Br J Cancer       Date:  1992-03       Impact factor: 7.640

7.  Extending the Scope of 19F Hyperpolarization through Signal Amplification by Reversible Exchange in MRI and NMR Spectroscopy.

Authors:  Alexandra M Olaru; Thomas B R Robertson; Jennifer S Lewis; Alex Antony; Wissam Iali; Ryan E Mewis; Simon B Duckett
Journal:  ChemistryOpen       Date:  2017-12-21       Impact factor: 2.911

8.  Non-invasive 19F MR spectroscopy of 5-fluorocytosine to 5-fluorouracil conversion by recombinant Salmonella in tumours.

Authors:  T Dresselaers; J Theys; S Nuyts; B Wouters; E de Bruijn; J Anné; P Lambin; P Van Hecke; W Landuyt
Journal:  Br J Cancer       Date:  2003-11-03       Impact factor: 7.640
  8 in total

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