| Literature DB >> 27015517 |
Marta Cicuendez1, Elena Martinez-Saez2, Francisco Martinez-Ricarte3, Esteban Cordero Asanza1, Juan Sahuquillo3.
Abstract
Combined pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) is an extremely rare tumor, with fewer than 20 cases reported. The authors report a case of combined PXA-GG in an 18-year-old man with a history of seizures. The tumor showed necrosis and the BRAF V600E mutation on histological examination, with no evidence of tumor recurrence 1 year after gross-total resection. The BRAF V600E mutation was present, which suggests that both cell lineages may share a common cellular origin.Entities:
Keywords: BRAF mutation; GFAP = glial fibrillary acidic protein; GG = ganglioglioma; PCR = polymerase chain reaction; PXA = pleomorphic xanthoastrocytoma; combined pleomorphic xanthoastrocytoma-ganglioglioma; ganglioglioma; oncology; pleomorphic xanthoastrocytoma
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Year: 2016 PMID： 27015517 DOI： 10.3171/2016.1.PEDS15558
Source DB: PubMed Journal: J Neurosurg Pediatr ISSN： 1933-0707 Impact factor: 2.375