| Literature DB >> 27015313 |
Francesca Ester Morreale1, Helen Walden1.
Abstract
Ubiquitination is a post-translational modification of proteins involved in a variety of cellular processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases). This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three families depending on the presence of characteristic domains and on the mechanism of ubiquitin transfer to the substrate protein.Mesh：
Substances：
Year: 2016 PMID： 27015313 DOI： 10.1016/j.cell.2016.03.003
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582