OBJECTIVE: To evaluate demographic data and clinical and laboratory features at disease diagnosis in 3 different age groups of childhood-onset systemic lupus erythematosus (SLE): group A, early-onset (<6 years); group B, school age (≥6 to <12 years); and group C, adolescent (≥12 to <18 years). METHODS: This was a Brazilian multicenter cohort retrospective study in 10 pediatric rheumatology centers, including 847 childhood-onset SLE patients. RESULTS: Patients were divided into 3 groups: group A with 39 patients (4%), group B with 395 patients (47%), and group C with 413 patients (49%). Of 39 childhood-onset SLE patients in group A, 3 (8%) were ages <2 years, 4 (10%) were ≥2 to <3 years, and 32 (82%) were ≥3 and <6 years. A total of 74 childhood-onset SLE patients were analyzed for C1q levels, and complete C1q deficiency was observed in 3 of 74 patients (4%), all in group A. Groups were similar regarding high frequencies of female sex, nephritis, neuropsychiatric involvement, Systemic Lupus Erythematosus Disease Activity Index 2000 score ≥8, autoantibody profile, elevated acute phase proteins, and low complement levels (P > 0.05). However, the frequency of fever (78% versus 61% versus 47%; P < 0.0001), hepatomegaly (42% versus 29% versus 14%; P < 0.0001), splenomegaly (28% versus 12% versus 4%; P < 0.0001), and discoid lupus (13% versus 4% versus 4%; P = 0.020) was significantly higher in group A compared to groups B and C. The frequency of weight loss >2 kg (19% versus 28% versus 36%; P = 0.017), photosensitivity (34% versus 41% versus 51%; P = 0.006), leukopenia <4,000/mm3 (14% versus 25% versus 30%; P = 0.048), and lymphopenia <1,500/mm3 (22% versus 41% versus 47%; P = 0.011) was significantly lower in group A. CONCLUSION: Our large multicenter study identified the finding that the initial appearance of childhood-onset SLE is characterized by comparable high frequency of internal organ involvement and some distinct clinical and laboratory features in early-onset and adolescent groups.
OBJECTIVE: To evaluate demographic data and clinical and laboratory features at disease diagnosis in 3 different age groups of childhood-onset systemic lupus erythematosus (SLE): group A, early-onset (<6 years); group B, school age (≥6 to <12 years); and group C, adolescent (≥12 to <18 years). METHODS: This was a Brazilian multicenter cohort retrospective study in 10 pediatric rheumatology centers, including 847 childhood-onset SLEpatients. RESULTS:Patients were divided into 3 groups: group A with 39 patients (4%), group B with 395 patients (47%), and group C with 413 patients (49%). Of 39 childhood-onset SLEpatients in group A, 3 (8%) were ages <2 years, 4 (10%) were ≥2 to <3 years, and 32 (82%) were ≥3 and <6 years. A total of 74 childhood-onset SLEpatients were analyzed for C1q levels, and complete C1q deficiency was observed in 3 of 74 patients (4%), all in group A. Groups were similar regarding high frequencies of female sex, nephritis, neuropsychiatric involvement, Systemic Lupus Erythematosus Disease Activity Index 2000 score ≥8, autoantibody profile, elevated acute phase proteins, and low complement levels (P > 0.05). However, the frequency of fever (78% versus 61% versus 47%; P < 0.0001), hepatomegaly (42% versus 29% versus 14%; P < 0.0001), splenomegaly (28% versus 12% versus 4%; P < 0.0001), and discoid lupus (13% versus 4% versus 4%; P = 0.020) was significantly higher in group A compared to groups B and C. The frequency of weight loss >2 kg (19% versus 28% versus 36%; P = 0.017), photosensitivity (34% versus 41% versus 51%; P = 0.006), leukopenia <4,000/mm3 (14% versus 25% versus 30%; P = 0.048), and lymphopenia <1,500/mm3 (22% versus 41% versus 47%; P = 0.011) was significantly lower in group A. CONCLUSION: Our large multicenter study identified the finding that the initial appearance of childhood-onset SLE is characterized by comparable high frequency of internal organ involvement and some distinct clinical and laboratory features in early-onset and adolescent groups.
Authors: Paola Pinheiro Kahwage; Mariana Paes Leme Ferriani; João M Furtado; Luciana Martins de Carvalho; Gecilmara Salviato Pileggi; Francisco Hugo Rodrigues Gomes; Maria Teresa Terreri; Claudia Saad Magalhães; Rosa Maria Rodrigues Pereira; Silvana Brasilia Sacchetti; Roberto Marini; Eloisa Bonfá; Clovis Artur Silva; Virgínia Paes Leme Ferriani Journal: Clin Rheumatol Date: 2017-01-09 Impact factor: 2.980
Authors: Juliana C O A Ferreira; Vitor C Trindade; Graciela Espada; Zoilo Morel; Eloisa Bonfá; Claudia S Magalhães; Clovis Artur Silva Journal: Clin Rheumatol Date: 2018-08-09 Impact factor: 2.980
Authors: Fernanda J Fiorot; Aline G Islabão; Rosa M Pereira; Maria T Terreri; Claudia Saad-Magalhães; Glaucia V Novak; Beatriz C Molinari; Ana P Sakamoto; Nadia E Aikawa; Lucia M Campos; Octavio A Peracchi; Simone Appenzeller; Virgínia P Ferriani; Marco F Silva; Adriana R Fonseca; Flávio R Sztajnbok; Luciana B Paim; Melissa M Fraga; Eunice M Okuda; Blanca E Bica; Evaldo G Sena; Ana J Moraes; Ana M Rolim; Paulo F Spelling; Iloite M Scheibel; André S Cavalcanti; Erica N Matos; Teresa C Robazzi; Luciano J Guimarães; Flávia P Santos; Valeria C Ramos; Magda Carneiro-Sampaio; Eloisa Bonfá; Clovis A Silva Journal: Clin Rheumatol Date: 2019-06-13 Impact factor: 2.980
Authors: Ana Paula Sakamoto; Clovis Artur Silva; Mariana Paes Leme Ferriani; Rosa Maria Rodrigues Pereira; Eloisa Bonfá; Claudia Saad-Magalhães; Eunice Okuda; Simone Appenzeller; Francisco Hugo Gomes; Ana Luiza Garcia Cunha; Mirna Henriques Tomich Salume; Daniela Petry Piotto; Maria Teresa Terreri Journal: Rheumatol Int Date: 2016-09-14 Impact factor: 2.631