Literature DB >> 2701469

The biosynthesis of branched O-glycans.

H Schachter1, I Brockhausen.   

Abstract

The hypothesis put forward in this review is that the branching patterns at the core of Ser(Thr)-GalNAc oligosaccharides (O-glycans) determine the types of glycan that are synthesized and their functions. Biosynthetic pathways are presented for the four types of O-glycan core and for some of the more common glycans that are built on these cores. The four core types discussed are: (1) Gal beta 1-3GalNAc-alpha-Ser(Thr)-R, (2) Gal beta 1-3(GlcNAc beta 1-6)GalNAc-alpha-Ser(Thr)-R, (3) GlcNAc beta 1-3GalNAc-alpha-Ser(Thr)-R, and (4) GlcNAc beta 1-3(GlcNAc beta 1-6)GalNAc-alpha-Ser(Thr)-R. General rules concerning the control of synthesis of these molecules are derived.

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Year:  1989        PMID： 2701469

Source DB:  PubMed          Journal:  Symp Soc Exp Biol        ISSN： 0081-1386


  16 in total

1.  Mucus glycoproteins, super glycoforms: how to solve a sticky problem?

Authors:  T Corfield
Journal:  Glycoconj J       Date:  1992-10       Impact factor: 2.916

Review 2.  Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.

Authors:  Alexander Zarbock; Klaus Ley; Rodger P McEver; Andrés Hidalgo
Journal:  Blood       Date:  2011-10-20       Impact factor: 22.113

3.  Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity.

Authors:  Mari Tenno; Kazuaki Ohtsubo; Fred K Hagen; David Ditto; Alexander Zarbock; Patrick Schaerli; Ulrich H von Andrian; Klaus Ley; Dzung Le; Lawrence A Tabak; Jamey D Marth
Journal:  Mol Cell Biol       Date:  2007-10-08       Impact factor: 4.272

4.  Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis.

Authors:  Steven J Van Dyken; Ryan S Green; Jamey D Marth
Journal:  Mol Cell Biol       Date:  2006-11-13       Impact factor: 4.272

5.  Cell-cell interactions influence oligosaccharide modifications on mucins and other large glycoproteins.

Authors:  P L Stranahan; J Laroe; R McCombs; A Goldsmith; I Rahim; M Overland; D E Pettijohn
Journal:  Glycoconj J       Date:  1996-10       Impact factor: 2.916

6.  Persistent repression of a functional allele can be responsible for galactosyltransferase deficiency in Tn syndrome.

Authors:  M Thurnher; S Rusconi; E G Berger
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

7.  Human preocular mucins reflect changes in surface physiology.

Authors:  M Berry; R B Ellingham; A P Corfield
Journal:  Br J Ophthalmol       Date:  2004-03       Impact factor: 4.638

8.  Recombinant human bile salt-stimulated lipase: an example of defective O-glycosylation of a protein produced in milk of transgenic mice.

Authors:  M Strömqvist; J Törnell; M Edlund; A Edlund; T Johansson; K Lindgren; L Lundberg; L Hansson
Journal:  Transgenic Res       Date:  1996-11       Impact factor: 2.788

9.  Glycosyltransferase function in core 2-type protein O glycosylation.

Authors:  Erica L Stone; Mohd Nazri Ismail; Seung Ho Lee; Ying Luu; Kevin Ramirez; Stuart M Haslam; Samuel B Ho; Anne Dell; Minoru Fukuda; Jamey D Marth
Journal:  Mol Cell Biol       Date:  2009-04-06       Impact factor: 4.272

Review 10.  Altered glycosylation in cancer: A promising target for biomarkers and therapeutics.

Authors:  Divya Thomas; Ashok Kumar Rathinavel; Prakash Radhakrishnan
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2020-11-04       Impact factor: 10.680
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