| Literature DB >> 27013376 |
Abigail K Langton1, Poonam Halai1, Christopher E M Griffiths1, Michael J Sherratt2, Rachel E B Watson3.
Abstract
The dermal-epidermal junction of human skin exhibits age-related remodelling, resulting in a flattened appearance and reduced surface area. Despite this, a paucity of information is available regarding which protein components change with advancing age. Here we report a significant reduction in the protein distribution of collagen IV (P<0.0001), collagen VII (P<0.001), collagen XVII (P<0.01), integrin β4 (P<0.001) and laminin-332 (P<0.0001) in intrinsically aged skin. The functional implication of this altered protein composition appears to be loss of structural integrity and may, in part, explain the increased fragility of aged skin.Entities:
Keywords: Dermal-epidermal junction; Intrinsic ageing
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Year: 2016 PMID： 27013376 DOI： 10.1016/j.mad.2016.03.006
Source DB: PubMed Journal: Mech Ageing Dev ISSN： 0047-6374 Impact factor: 5.432