Literature DB >> 27013211

UCH-L1 in DLBCL: marker or target?

Joseph S Pagano1, Julia Shackelford1.   

Abstract

In this issue of Blood, Bedekovics et al have demonstrated that a multifunctional molecule of the ubiquitin system ubiquitin C-terminal hydrolase L1 (UCH-L1) is induced in diffuse large B-cell lymphomas (DLBCLs), and that levels of this molecule are higher in germinal center (GC) B-cell DLBCL (GCB-DLBCL) compared with activated B-cell DLBCL (ABC-DLBCL) and predict poor outcomes.

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Year:  2016        PMID： 27013211      PMCID： PMC5459223          DOI： 10.1182/blood-2016-01-689984

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  10 in total

1.  The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.

Authors:  S Hussain; O Foreman; S L Perkins; T E Witzig; R R Miles; J van Deursen; P J Galardy
Journal:  Leukemia       Date:  2010-06-24       Impact factor: 11.528

2.  PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells.

Authors:  Anjali Bheda; Wei Yue; Anuradha Gullapalli; Julia Shackelford; Joseph S Pagano
Journal:  Leuk Lymphoma       Date:  2011-04-20

3.  UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.

Authors:  Tibor Bedekovics; Sajjad Hussain; Andrew L Feldman; Paul J Galardy
Journal:  Blood       Date:  2015-12-23       Impact factor: 22.113

4.  The regulation of the UCH-L1 gene by transcription factor NF-κB in podocytes.

Authors:  Hongxia Zhang; Yu Sun; Ruimin Hu; Weili Luo; Xing Mao; Zhonghua Zhao; Qi Chen; Zhigang Zhang
Journal:  Cell Signal       Date:  2013-04-06       Impact factor: 4.315

Review 5.  Ubiquitin carboxyl hydrolase L1 significance for human diseases.

Authors:  Dang Ngoc Anh Suong; Dang Thi Phuong Thao; Yamaguchi Masamitsu; Tran Linh Thuoc
Journal:  Protein Pept Lett       Date:  2014-07       Impact factor: 1.890

6.  Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.

Authors:  Huib Ovaa; Benedikt M Kessler; Ulrika Rolén; Paul J Galardy; Hidde L Ploegh; Maria G Masucci
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-24       Impact factor: 11.205

7.  Ubiquitin C-terminal hydrolase l1 in tumorigenesis.

Authors:  Jennifer Hurst-Kennedy; Lih-Shen Chin; Lian Li
Journal:  Biochem Res Int       Date:  2012-07-01

8.  UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.

Authors:  Yoko Goto; Lihua Zeng; Chan Joo Yeom; Yuxi Zhu; Akiyo Morinibu; Kazumi Shinomiya; Minoru Kobayashi; Kiichi Hirota; Satoshi Itasaka; Michio Yoshimura; Keiji Tanimoto; Masae Torii; Terumasa Sowa; Toshi Menju; Makoto Sonobe; Hideaki Kakeya; Masakazu Toi; Hiroshi Date; Ester M Hammond; Masahiro Hiraoka; Hiroshi Harada
Journal:  Nat Commun       Date:  2015-01-23       Impact factor: 14.919

9.  Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes.

Authors:  Anjali Bheda; Julia Shackelford; Joseph S Pagano
Journal:  PLoS One       Date:  2009-08-26       Impact factor: 3.240

10.  Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling.

Authors:  Anjali Bheda; Wei Yue; Anuradha Gullapalli; Chris Whitehurst; Renshui Liu; Joseph S Pagano; Julia Shackelford
Journal:  PLoS One       Date:  2009-06-18       Impact factor: 3.240
  10 in total

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