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Literature DB >> 27012772

5-HT4-mediated neuroprotection: a new therapeutic modality on the way?

Michael D Gershon¹.

Abstract

Mesh：

Substances：

Year: 2016 PMID： 27012772 PMCID： PMC4888548 DOI： 10.1152/ajpgi.00120.2016

Source DB: PubMed Journal: Am J Physiol Gastrointest Liver Physiol ISSN： 0193-1857 Impact factor: 4.052

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12 in total

1. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons.

Authors: Zhishan Li; Alcmène Chalazonitis; Yung-Yu Huang; J John Mann; Kara Gross Margolis; Qi Melissa Yang; Dolly O Kim; Francine Côté; Jacques Mallet; Michael D Gershon
Journal: J Neurosci Date: 2011-06-15 Impact factor: 6.167

2. Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon.

Authors: D R Linden; J M Couvrette; A Ciolino; C McQuoid; H Blaszyk; K A Sharkey; G M Mawe
Journal: Neurogastroenterol Motil Date: 2005-10 Impact factor: 3.598

3. Neuronal serotonin regulates growth of the intestinal mucosa in mice.

Authors: Erica R Gross; Michael D Gershon; Kara G Margolis; Zoya V Gertsberg; Zhishan Li; Robert A Cowles
Journal: Gastroenterology Date: 2012-05-15 Impact factor: 22.682

4. Prucalopride exerts neuroprotection in human enteric neurons.

Authors: Francesca Bianco; Elena Bonora; Dipa Natarajan; Manuela Vargiolu; Nikhil Thapar; Francesco Torresan; Fiorella Giancola; Elisa Boschetti; Umberto Volta; Franco Bazzoli; Maurizio Mazzoni; Marco Seri; Paolo Clavenzani; Vincenzo Stanghellini; Catia Sternini; Roberto De Giorgio
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2016-02-18 Impact factor: 4.052

5. Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.

Authors: Jill M Hoffman; Karl Tyler; Sarah J MacEachern; Onesmo B Balemba; Anthony C Johnson; Elice M Brooks; Hong Zhao; Greg M Swain; Peter L Moses; James J Galligan; Keith A Sharkey; Beverley Greenwood-Van Meerveld; Gary M Mawe
Journal: Gastroenterology Date: 2012-01-04 Impact factor: 22.682

Review 6. 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract.

Authors: Michael D Gershon
Journal: Curr Opin Endocrinol Diabetes Obes Date: 2013-02 Impact factor: 3.243

7. Serotonin has a key role in pathogenesis of experimental colitis.

Authors: Jean-Eric Ghia; Nan Li; Huaqing Wang; Matthew Collins; Yikang Deng; Rami T El-Sharkawy; Francine Côté; Jacques Mallet; Waliul I Khan
Journal: Gastroenterology Date: 2009-08-23 Impact factor: 22.682

8. Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice.

Authors: Stephan C Bischoff; Reiner Mailer; Oliver Pabst; Gisela Weier; Wanda Sedlik; Zhishan Li; Jason J Chen; Dennis L Murphy; Michael D Gershon
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2008-12-18 Impact factor: 4.052

5-HT4-mediated neuroprotection: a new therapeutic modality on the way?

1. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons.

2. Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon.

3. Neuronal serotonin regulates growth of the intestinal mucosa in mice.

4. Prucalopride exerts neuroprotection in human enteric neurons.

5. Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.

Review 6. 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract.

7. Serotonin has a key role in pathogenesis of experimental colitis.

8. Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice.

9. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense.

10. Enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide.

1. Prucalopride exerts neuroprotection in human enteric neurons.

Review 2. Novel aspects of enteric serotonergic signaling in health and brain-gut disease.

Review 3. Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.

Review 4. Enteric Neuronal Regulation of Intestinal Inflammation.

5. Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway.