Onno A Spruijt1, Maria C Di Pasqua2, H J Bogaard1, C E E van der Bruggen1, Frank Oosterveer1, J Tim Marcus3, Anton Vonk-Noordegraaf4, M Louis Handoko5. 1. Department of Pulmonary Medicine, VU University Medical Center, Amsterdam, The Netherlands. 2. Department of Pulmonary Medicine, VU University Medical Center, Amsterdam, The Netherlands; Department of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy. 3. Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands. 4. Department of Pulmonary Medicine, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: a.vonk@vumc.nl. 5. Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands.
Abstract
BACKGROUND: Although cardiac magnetic resonance imaging (CMRI) is the gold standard for the (serial) assessment of right ventricular (RV) function, the technique has several drawbacks: CMRI is relatively expensive, has a limited availability, and the analyses are time consuming. Echocardiography (echo) can overcome several of these issues. The aim of this study was to compare simple echo-derived parameters of RV systolic function with CMRI-derived RV ejection fraction (RVEF) in patients with precapillary pulmonary hypertension (PH) and to determine which echo parameters best followed the change in CMRI-derived-RVEF during follow-up. METHODS: CMRI and echo were performed in 96 precapillary PH patients. In 38 patients a second set of a CMRI and echo were available. Retrospectively, echo-derived right ventricular fractional area change (RVFAC), tricuspid annulus plane systolic excursion (TAPSE), fractional transversal (FTWM), and longitudinal wall motion (FLWM) were assessed and compared with CMRI-derived-RVEF. Furthermore, the changes in RVFAC, TAPSE, FTWM, and FLWM during follow-up were compared with the change in CMRI-derived-RVEF. RESULTS: All four echo parameters were significantly correlated to CMRI-derived-RVEF. The strongest relationship was seen between CMRI-derived-RVEF and RVFAC (r2=0.567). However, sensitivity for predicting a deterioration in CMRI-derived RVEF was poor for all four echo-derived parameters (ranging from 33% to 56%). CONCLUSIONS: Although RVFAC, TAPSE, FTWM, and FLWM were significantly correlated to CMRI-derived-RVEF, all four echo parameters showed a low sensitivity for predicting a deterioration in CMRI-derived RVEF during follow-up. Therefore, RVFAC, TAPSE, FTWM, and FLWM are not suitable parameters for the serial assessment of RV systolic function in patients with precapillary PH.
BACKGROUND: Although cardiac magnetic resonance imaging (CMRI) is the gold standard for the (serial) assessment of right ventricular (RV) function, the technique has several drawbacks: CMRI is relatively expensive, has a limited availability, and the analyses are time consuming. Echocardiography (echo) can overcome several of these issues. The aim of this study was to compare simple echo-derived parameters of RV systolic function with CMRI-derived RV ejection fraction (RVEF) in patients with precapillary pulmonary hypertension (PH) and to determine which echo parameters best followed the change in CMRI-derived-RVEF during follow-up. METHODS: CMRI and echo were performed in 96 precapillary PH patients. In 38 patients a second set of a CMRI and echo were available. Retrospectively, echo-derived right ventricular fractional area change (RVFAC), tricuspid annulus plane systolic excursion (TAPSE), fractional transversal (FTWM), and longitudinal wall motion (FLWM) were assessed and compared with CMRI-derived-RVEF. Furthermore, the changes in RVFAC, TAPSE, FTWM, and FLWM during follow-up were compared with the change in CMRI-derived-RVEF. RESULTS: All four echo parameters were significantly correlated to CMRI-derived-RVEF. The strongest relationship was seen between CMRI-derived-RVEF and RVFAC (r2=0.567). However, sensitivity for predicting a deterioration in CMRI-derived RVEF was poor for all four echo-derived parameters (ranging from 33% to 56%). CONCLUSIONS: Although RVFAC, TAPSE, FTWM, and FLWM were significantly correlated to CMRI-derived-RVEF, all four echo parameters showed a low sensitivity for predicting a deterioration in CMRI-derived RVEF during follow-up. Therefore, RVFAC, TAPSE, FTWM, and FLWM are not suitable parameters for the serial assessment of RV systolic function in patients with precapillary PH.
Authors: Tim Lahm; Ivor S Douglas; Stephen L Archer; Harm J Bogaard; Naomi C Chesler; Francois Haddad; Anna R Hemnes; Steven M Kawut; Jeffrey A Kline; Todd M Kolb; Stephen C Mathai; Olaf Mercier; Evangelos D Michelakis; Robert Naeije; Rubin M Tuder; Corey E Ventetuolo; Antoine Vieillard-Baron; Norbert F Voelkel; Anton Vonk-Noordegraaf; Paul M Hassoun Journal: Am J Respir Crit Care Med Date: 2018-08-15 Impact factor: 21.405
Authors: Antoine Vieillard-Baron; R Naeije; F Haddad; H J Bogaard; T M Bull; N Fletcher; T Lahm; S Magder; S Orde; G Schmidt; M R Pinsky Journal: Intensive Care Med Date: 2018-05-09 Impact factor: 17.440
Authors: Hideo Arai; Masateru Kawakubo; Kenichi Sanui; Ryoji Iwamoto; Hiroshi Nishimura; Toshiaki Kadokami Journal: Int J Environ Res Public Health Date: 2022-01-27 Impact factor: 3.390
Authors: Steffen D Kriechbaum; Julia M Vietheer; Christoph B Wiedenroth; Felix Rudolph; Marta Barde; Jan-Sebastian Wolter; Moritz Haas; Ulrich Fischer-Rasokat; Maren Weferling; Andreas Rolf; Christian W Hamm; Eckhard Mayer; Stefan Guth; Till Keller; Fritz C Roller; Christoph Liebetrau Journal: Pulm Circ Date: 2021-12-10 Impact factor: 3.017
Authors: Mieke M P Driessen; Tim Leiner; Gertjan Tj Sieswerda; Arie P J van Dijk; Marco C Post; Mark K Friedberg; Luc Mertens; Pieter A Doevendans; Repke J Snijder; Erik H Hulzebos; Folkert J Meijboom Journal: PLoS One Date: 2018-10-24 Impact factor: 3.240
Authors: Marcelo M Mello; Guilherme Watte; Stephan Altmayer; Yana L R Pallaoro; Fernanda B Spilimbergo; Daniela C Blanco; Gisela M B Meyer; Edson Marchiori; Bruno Hochhegger Journal: Radiol Bras Date: 2019 Nov-Dec