Tamara Strohm1, Burhan Chaudhry2, Mary A Willis2, Steven Shook2. 1. Department of Neurology, Cleveland Clinic, Cleveland, OH, USA tamara.strohm@gmail.com strohmt@ccf.org. 2. Department of Neurology, Cleveland Clinic, Cleveland, OH, USA.
Abstract
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) has been associated with multiple medications, cocaine, pregnancy, migraine, and other conditions. OBJECTIVES: RCVS associated with interferon beta use has never before been described. METHODS: We describe the case of a 20-year-old female who developed acute onset severe headache and was found to have subarachnoid hemorrhage 2 months after initiating Rebif (Interferon beta-1a) for multiple sclerosis (MS). Cerebral angiography showed multiple areas of distal stenosis and dilatation with radiographic resolution 1 month later. RESULTS/ CONCLUSIONS: This is the first case report of RCVS in an MS patient treated with Rebif.
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) has been associated with multiple medications, cocaine, pregnancy, migraine, and other conditions. OBJECTIVES: RCVS associated with interferon beta use has never before been described. METHODS: We describe the case of a 20-year-old female who developed acute onset severe headache and was found to have subarachnoid hemorrhage 2 months after initiating Rebif (Interferon beta-1a) for multiple sclerosis (MS). Cerebral angiography showed multiple areas of distal stenosis and dilatation with radiographic resolution 1 month later. RESULTS/ CONCLUSIONS: This is the first case report of RCVS in an MSpatient treated with Rebif.
Authors: Ilkka Rauma; Tiina Mustonen; Juha Matti Seppä; Maritta Ukkonen; Marianne Männikkö; Auli Verkkoniemi-Ahola; Marge Kartau; Jukka T Saarinen; Liisa Luostarinen; Sakari Simula; Mervi Ryytty; Riitta Ahmasalo; Jussi O T Sipilä; Ilkka Pieninkeroinen; Tero Tapiola; Anne M Remes; Hanna Kuusisto Journal: J Neurol Date: 2021-07-13 Impact factor: 4.849