Suzan Tabur1, Serdar Oztuzcu2, Elif Oguz3, Seniz Demiryürek4, Hasan Dagli2, Belgin Alasehirli5, Mesut Ozkaya6, Abdullah T Demiryürek5. 1. Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. Electronic address: suzan2471@yahoo.com.tr. 2. Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. 3. Department of Medical Pharmacology, Faculty of Medicine, Harran University, Sanliurfa, Turkey. 4. Department of Physiology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. 5. Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. 6. Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
Abstract
PURPOSE: The contribution of cytochrome P450 (CYP) gene expressions in metabolic syndrome (MetS) has not been elucidated, and was the aim of this study. METHODS: A total of 51 MetS patients and 41 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a dynamic array system. RESULTS: We observed marked suppressions in CYP2A6 (p=0.0123), CYP4F2 (p=0.0005), CYP3A5 (p=0.0003), and CYP17A1 (p<0.0001) gene expressions in MetS patients. CONCLUSIONS: This is the first study to provide evidence that depressed expressions of CYP2A6, CYP4F2, CYP3A5, and CYP17A1 genes may play a role in MetS.
PURPOSE: The contribution of cytochrome P450 (CYP) gene expressions in metabolic syndrome (MetS) has not been elucidated, and was the aim of this study. METHODS: A total of 51 MetS patients and 41 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a dynamic array system. RESULTS: We observed marked suppressions in CYP2A6 (p=0.0123), CYP4F2 (p=0.0005), CYP3A5 (p=0.0003), and CYP17A1 (p<0.0001) gene expressions in MetS patients. CONCLUSIONS: This is the first study to provide evidence that depressed expressions of CYP2A6, CYP4F2, CYP3A5, and CYP17A1 genes may play a role in MetS.
Authors: María D Ronquillo; Alla Mellnyk; Noemí Cárdenas-Rodríguez; Emmanuel Martínez; David A Comoto; Liliana Carmona-Aparicio; Norma E Herrera; Eleazar Lara; Armando Pereyra; Esaú Floriano-Sánchez Journal: Indian J Med Res Date: 2019-05 Impact factor: 2.375