OBJECTIVE: Endothelial dysfunction is involved in inflammatory disorders, migration, angiogenesis, and tumor progression. There is a known relationship between migraine and inflammation; however, there are conflicting data as to whether there is a link between migraine and endothelial dysfunction. The current study aimed to determine the relationships between migraine and levels of serum Endocan (ESM-1), Claudin-5 (CLDN5), IL-1β, IL-6 and TNF-α levels, which are proven indicators of endothelial dysfunction and inflammation in patients with migraine. PATIENTS AND METHODS: Thirty-one patients and 24 healthy subjects were included in this study. Participants underwent thorough physical and neurological evaluations, and levels of serum ESM-1, CLDN5, IL-1β, IL-6 and TNF-α were measured for each patient. RESULTS: The levels of ESM-1, CLDN5, IL-1β, IL-6, and TNF-α were significantly higher in the migraine attack group than in the control group (p: 0.006, p: 0.002, p: 0.002, p: 0.003, p: 0.036, respectively). Additionally, there were significant differences in the ESM-1 levels of the visual analog scale (VAS) subgroup (p = 0.041), and there were moderate differences in the CLDN5 levels of the VAS subgroup (p = 0.064). CONCLUSIONS: High serum levels of IL-1β, IL-6 and TNF-α in the migraine attack group indicate that inflammation plays a major role in migraine pathogenesis. In particular, the high ESM-1 and CLDN5 levels in patients with migraine suggest that inflammation should be investigated further, it may be a useful tool in the differential diagnosis of migraine.
OBJECTIVE:Endothelial dysfunction is involved in inflammatory disorders, migration, angiogenesis, and tumor progression. There is a known relationship between migraine and inflammation; however, there are conflicting data as to whether there is a link between migraine and endothelial dysfunction. The current study aimed to determine the relationships between migraine and levels of serum Endocan (ESM-1), Claudin-5 (CLDN5), IL-1β, IL-6 and TNF-α levels, which are proven indicators of endothelial dysfunction and inflammation in patients with migraine. PATIENTS AND METHODS: Thirty-one patients and 24 healthy subjects were included in this study. Participants underwent thorough physical and neurological evaluations, and levels of serum ESM-1, CLDN5, IL-1β, IL-6 and TNF-α were measured for each patient. RESULTS: The levels of ESM-1, CLDN5, IL-1β, IL-6, and TNF-α were significantly higher in the migraine attack group than in the control group (p: 0.006, p: 0.002, p: 0.002, p: 0.003, p: 0.036, respectively). Additionally, there were significant differences in the ESM-1 levels of the visual analog scale (VAS) subgroup (p = 0.041), and there were moderate differences in the CLDN5 levels of the VAS subgroup (p = 0.064). CONCLUSIONS: High serum levels of IL-1β, IL-6 and TNF-α in the migraine attack group indicate that inflammation plays a major role in migraine pathogenesis. In particular, the high ESM-1 and CLDN5 levels in patients with migraine suggest that inflammation should be investigated further, it may be a useful tool in the differential diagnosis of migraine.
Authors: Dilyara Nurkhametova; Igor Kudryavtsev; Olga Khayrutdinova; Maria Serebryakova; Rashid Altunbaev; Tarja Malm; Rashid Giniatullin Journal: Front Cell Neurosci Date: 2018-09-25 Impact factor: 5.505