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Literature DB >> 27009960

Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions.

Sarah S Wilson¹, Mayim E Wiens¹, Mayumi K Holly¹, Jason G Smith².

Abstract

Defensins are innate immune effector peptides expressed at mucosal surfaces throughout the human body and are potently antiviral in vitro The role of defensins in viral pathogenesis in vivo is poorly understood; however, recent studies have revealed that defensin-virus interactions in vivo are complicated and distinct from their proposed antiviral mechanisms in vitro These findings highlight the need for additional research that connects defensin neutralization of viruses in cell culture to in vivo antiviral mechanisms.

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Year: 2016 PMID： 27009960 PMCID： PMC4934752 DOI： 10.1128/JVI.00904-15

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

26 in total

Review 1. α-Defensins in human innate immunity.

Authors: Robert I Lehrer; Wuyuan Lu
Journal: Immunol Rev Date: 2012-01 Impact factor: 12.988

2. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins.

Authors: J W Lillard; P N Boyaka; O Chertov; J J Oppenheim; J R McGhee
Journal: Proc Natl Acad Sci U S A Date: 1999-01-19 Impact factor: 11.205

3. Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity.

Authors: Lisa K Ryan; Jihong Dai; Zhiwei Yin; Nicholas Megjugorac; Victoria Uhlhorn; Sunghan Yim; Kyell D Schwartz; Joshua M Abrahams; Gill Diamond; Patricia Fitzgerald-Bocarsly
Journal: J Leukoc Biol Date: 2011-05-06 Impact factor: 4.962

4. Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens.

Authors: K Tani; W J Murphy; O Chertov; R Salcedo; C Y Koh; I Utsunomiya; S Funakoshi; O Asai; S H Herrmann; J M Wang; L W Kwak; J J Oppenheim
Journal: Int Immunol Date: 2000-05 Impact factor: 4.823

5. Alpha-defensin HD5 inhibits furin cleavage of human papillomavirus 16 L2 to block infection.

Authors: Mayim E Wiens; Jason G Smith
Journal: J Virol Date: 2014-12-24 Impact factor: 5.103

6. Mechanism of adenovirus neutralization by Human alpha-defensins.

Authors: Jason G Smith; Glen R Nemerow
Journal: Cell Host Microbe Date: 2008-01-17 Impact factor: 21.023

7. Altered α-defensin 5 expression in cervical squamocolumnar junction: implication in the formation of a viral/tumour-permissive microenvironment.

Authors: Pascale Hubert; Ludivine Herman; Patrick Roncarati; Catherine Maillard; Virginie Renoux; Stéphanie Demoulin; Charlotte Erpicum; Jean-Michel Foidart; Jacques Boniver; Agnès Noël; Philippe Delvenne; Michael Herfs
Journal: J Pathol Date: 2014-10-06 Impact factor: 7.996

8. Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells.

Authors: Rossana Herrera; Michael Morris; Kristina Rosbe; Zhimin Feng; Aaron Weinberg; Sharof Tugizov
Journal: Virology Date: 2015-11-02 Impact factor: 3.616

9. Contribution of a single host genetic locus to mouse adenovirus type 1 infection and encephalitis.

Authors: Tien-Huei Hsu; Irene W Althaus; Oded Foreman; Katherine R Spindler
Journal: MBio Date: 2012-05-29 Impact factor: 7.867

10. Delineation of interfaces on human alpha-defensins critical for human adenovirus and human papillomavirus inhibition.

Authors: Victoria R Tenge; Anshu P Gounder; Mayim E Wiens; Wuyuan Lu; Jason G Smith
Journal: PLoS Pathog Date: 2014-09-04 Impact factor: 6.823

17 in total

1. Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy.

Authors: Charles Vragniau; Jens-Martin Hübner; Peter Beidler; Sucheol Gil; Kamola Saydaminova; Zhuo-Zhuang Lu; Roma Yumul; Hongjie Wang; Maximilian Richter; Pavel Sova; Charles Drescher; Pascal Fender; André Lieber
Journal: J Virol Date: 2017-02-28 Impact factor: 5.103

2. Novel role of surfactant protein A in bacterial sinusitis.

Authors: George T Noutsios; Amanda L Willis; Julie G Ledford; Eugene H Chang
Journal: Int Forum Allergy Rhinol Date: 2017-07-20 Impact factor: 3.858

Review 3. The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy.

Authors: I-Ni Hsieh; Kevan L Hartshorn
Journal: Pharmaceuticals (Basel) Date: 2016-09-06

Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions.

Review 1. α-Defensins in human innate immunity.

2. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins.

3. Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity.

4. Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens.

5. Alpha-defensin HD5 inhibits furin cleavage of human papillomavirus 16 L2 to block infection.

6. Mechanism of adenovirus neutralization by Human alpha-defensins.

7. Altered α-defensin 5 expression in cervical squamocolumnar junction: implication in the formation of a viral/tumour-permissive microenvironment.

8. Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells.

9. Contribution of a single host genetic locus to mouse adenovirus type 1 infection and encephalitis.

10. Delineation of interfaces on human alpha-defensins critical for human adenovirus and human papillomavirus inhibition.

1. Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy.

2. Novel role of surfactant protein A in bacterial sinusitis.

Review 3. The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy.

4. Urban particulate matter (PM) suppresses airway antibacterial defence.

5. Alpha-defensin-dependent enhancement of enteric viral infection.

Review 6. Modulation of Human β-Defensin-1 Production by Viruses.

Review 7. Guardians of the Gut: Enteric Defensins.

Review 8. Towards the Application of Human Defensins as Antivirals.

Review 9. Antiviral Activities of Human Host Defense Peptides.

Review 10. The Regulation of Inflammation by Innate and Adaptive Lymphocytes.