Increased neutrophil to lymphocyte ratio in persons suffering from hypertension with hyperhomocysteinemia.

The neutrophil to lymphocyte ratio (NLR) is increased in various cardiovascular diseases. The objective of this study is to determine whether the NLR is increased in persons suffering from hypertension with hyperhomocysteinemia (HTH). We retrospectively analyzed the results of a large cohort of individuals undergoing health examinations with respect to NLR values, homocysteine (HCY) concentration, total cholesterol, triglyceride (TG) concentration, glucose concentration, creatinine (Cr) concentration, smoking status, drinking status and blood pressure. When participants were grouped according to the NLR quartiles, there were strong, graded increases in HCY (P<0.001) and the numbers of patients suffering from HTH were up to two-fold higher in the fourth vs. the first quartile. The NLR of the participants suffering from HTH group was significantly higher than the participants suffering from hypertension in the non-HTH group and the normotension group. In an unconditional multiple logistic regression analysis, NLR predicted HTH independently of age, sex, body mass index, smoking, drinking, TG and Cr. The present study demonstrated that the NLR value increased in the HTH group and positively correlated with HCY but not with blood pressure.