Ijeoma N Diaku-Akinwumi1, Sani B Abubakar2, Samuel A Adegoke3, Solomon Adeleke4, Oyebade Adewoye5, Titilayo Adeyemo6, Akinsegun Akinbami7, Norah O Akinola8, Adebola Akinsulie9, Adeline Akinyoola10, John Aneke11, Sani Awwalu12, Ahmadu Babadoko12, Biobele Brown13, Obuoha Ejike14, Ifeoma Emodi15, Innocent George16, Ahmed Girei17, Abdulaziz Hassan12, Garba U Kangiwa18, Olubunmi A Lawal19, Cecilia Mabogunje20, Anazoeze J Madu21, Akeem Mustapha22, Muhammad Ndakotsu2, Obiageli E Nnodu4, Damian Nwaneri23, Friday Odey F24, Chinatu Ohiaeri25, Rasaq Olaosebikan26, Oladele S Olatunya O27, Oluseyi Oniyangi28, Hyginus Opara29, Ngozi I Ugwu30, Abubakar U Musa2, Shehu Abdullahi31, Abubakar Usman32, Enobong Utuk33, Binta W Jibir34, Adekunle D Adekile35. 1. Department of Pediatrics, Lagos State University Teaching Hospital. 2. Department of Pediatrics, Uthman Danfodio University Teaching Hospital, Sokoto. 3. Department of Pediatrics, Wesley Guild Hospital, Ilesa Unit, Obafemi Awolowo University Teaching Hospital. 4. Department of Pediatrics, University of Abuja and University of Abuja Teaching Hospital, Abuja. 5. Department of Hematology, General Hospital, Katsina. 6. Department of Hematology, Lagos University Teaching Hospital. 7. Department of Hematology, Lagos State University Teaching Hospital. 8. Department of Hematology, Obafemi Awolowo University, Ile-Ife. 9. Department of Pediatrics, Lagos University Teaching Hospital. 10. Gbagada General Hospital, Lagos. 11. Nnamdi Azikiwe University Teaching Hospital. 12. Ahmadu Bello University Teaching Hospital, Zaria. 13. Department of Pediatrics, University College Hospital, Ibadan. 14. Enugu State University Teaching Hospital, Parklane. 15. Department of Pediatrics, University of Nigeria Teaching Hospital, Enugu. 16. Department of Pediatrics, University of Port Harcourt Teaching Hospital. 17. Federal Medical Center, Gombe. 18. Federal Medical Center, Birnin Kebbi. 19. Department of Pediatrics, Federal Medical Center, Iddo-Ekiti. 20. Massey Street Children's Hospital. 21. Department of Hematology, University of Nigeria Teaching Hospital, Enugu. 22. Ifako-Ijaiye General Hospital, Lagos. 23. Department of Hematology, Department of Child Health, University of Benin Teaching Hospital. 24. Department of Pediatrics University of Calabar Teaching Hospital. 25. Department of Pediatrics, Federal Medical Center, Keffi. 26. Department of Pediatrics, University of Ilorin Teaching Hospital. 27. Department of Pediatrics, Ekiti State University, Ado Ekiti. 28. Department of Pediatrics, National Hospital, Abuja. 29. Department of Pediatrics, Federal Medical Center, Asaba. 30. Department of Haematology, Federal Teaching Hospital, Abakaliki. 31. Department of Pediatrics, Aminu Kano Teaching Hospital, Kano. 32. Department of Pediatrics, Federal Medical Center, Bida. 33. Department of Pediatrics, University of Uyo Teaching Hospital, Uyo. 34. Department of Pediatrics, Murtala Muhammed Specialist Hospital Kano. 35. Department of Pediatrics, Kuwait University adekile@hsc.edu.kw.
Abstract
BACKGROUND: Safe, timely red blood cell transfusion saves lives and chronic transfusion therapy (CTT) prevents or limits morbidities such as stroke, therefore improving quality of life of patients with sickle cell disease (SCD). METHODS: This questionnaire-based study assessed the ability of sickle cell centers in Nigeria to provide safe blood to patients with SCD between March and August 2014. RESULTS: Out of the 73 hospitals contacted, responses were obtained from 31. Twenty four (78%) hospitals were unable to transfuse patients regularly due to blood scarcity. Packed red blood cells were available in 14 (45%), while only one provided leukocyte-depletion. Most centers assessed donor risk and screened for HIV in 30 (97%), hepatitis B in 31(100%) and hepatitis C in 27 (87%) hospitals. Extended phenotyping and alloantibody screening were not available in any center. A quarter of the hospitals could monitor iron overload, but only using serum ferritin. Access to iron chelators was limited and expensive. Seventeen (55%) tertiary hospitals offered CTT by top-up or manual exchange transfusion; previous stroke was the most common indication. CONCLUSION: Current efforts of Nigerian public hospitals to provide safe blood and CTT fall short of best practice. Provision of apheresis machines, improvement of voluntary non-remunerated donor drive, screening for red cell antigens and antibodies, and availability of iron chelators would significantly improve SCD care in Nigeria.
BACKGROUND: Safe, timely red blood cell transfusion saves lives and chronic transfusion therapy (CTT) prevents or limits morbidities such as stroke, therefore improving quality of life of patients with sickle cell disease (SCD). METHODS: This questionnaire-based study assessed the ability of sickle cell centers in Nigeria to provide safe blood to patients with SCD between March and August 2014. RESULTS: Out of the 73 hospitals contacted, responses were obtained from 31. Twenty four (78%) hospitals were unable to transfuse patients regularly due to blood scarcity. Packed red blood cells were available in 14 (45%), while only one provided leukocyte-depletion. Most centers assessed donor risk and screened for HIV in 30 (97%), hepatitis B in 31(100%) and hepatitis C in 27 (87%) hospitals. Extended phenotyping and alloantibody screening were not available in any center. A quarter of the hospitals could monitor iron overload, but only using serum ferritin. Access to iron chelators was limited and expensive. Seventeen (55%) tertiary hospitals offered CTT by top-up or manual exchange transfusion; previous stroke was the most common indication. CONCLUSION: Current efforts of Nigerian public hospitals to provide safe blood and CTT fall short of best practice. Provision of apheresis machines, improvement of voluntary non-remunerated donor drive, screening for red cell antigens and antibodies, and availability of iron chelators would significantly improve SCD care in Nigeria.
Authors: Oladele S Olatunya; Dulcineia M Albuquerque; Adekunle Adekile; Fernando F Costa Journal: J Clin Lab Anal Date: 2018-08-20 Impact factor: 2.352
Authors: Walufu Ivan Egesa; Gloria Nakalema; William M Waibi; Munanura Turyasiima; Emmanuel Amuje; Gloria Kiconco; Simon Odoch; Patrick Kumbowi Kumbakulu; Said Abdirashid; Daniel Asiimwe Journal: Int J Pediatr Date: 2022-10-08