Haichun Yang1, Agnes B Fogo, Valentina Kon. 1. aDepartments of Pediatrics, Microbiology, and Immunology bDepartments of Medicine, Microbiology, and Immunology cDepartments of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Abstract
PURPOSE OF REVIEW: The review will examine advances in our understanding of the role kidneys play in high-density lipoprotein (HDL) metabolism and the effect on levels, composition, and function of HDL particles. RECENT FINDINGS: Components of the HDL particles can cross the glomerular filtration barrier. Some of these components, including apolipoproteins and enzymes involved in lipid metabolism, are taken up by the proximal tubule and degraded, modified, salvaged/returned to the circulation, or lost in the urine. Injury of the glomerular capillaries or tubules can affect these intrarenal processes and modify HDL. Changes in the plasma and urine levels of HDL may be novel markers of kidney damage or mechanism(s) of kidney disease. SUMMARY: The kidneys have a significant role in the metabolism of individual HDL components, which in turn modulate HDL levels, composition, and functionality of HDL particles. These intrarenal effects may be useful markers of kidney damage and have consequences on kidney-related perturbations in HDL.
PURPOSE OF REVIEW: The review will examine advances in our understanding of the role kidneys play in high-density lipoprotein (HDL) metabolism and the effect on levels, composition, and function of HDL particles. RECENT FINDINGS: Components of the HDL particles can cross the glomerular filtration barrier. Some of these components, including apolipoproteins and enzymes involved in lipid metabolism, are taken up by the proximal tubule and degraded, modified, salvaged/returned to the circulation, or lost in the urine. Injury of the glomerular capillaries or tubules can affect these intrarenal processes and modify HDL. Changes in the plasma and urine levels of HDL may be novel markers of kidney damage or mechanism(s) of kidney disease. SUMMARY: The kidneys have a significant role in the metabolism of individual HDL components, which in turn modulate HDL levels, composition, and functionality of HDL particles. These intrarenal effects may be useful markers of kidney damage and have consequences on kidney-related perturbations in HDL.
Authors: Obaidullah Aseem; Brian T Smith; Marion A Cooley; Brent A Wilkerson; Kelley M Argraves; Alan T Remaley; W Scott Argraves Journal: J Am Soc Nephrol Date: 2013-12-19 Impact factor: 10.121
Authors: Anand Rohatgi; Amit Khera; Jarett D Berry; Edward G Givens; Colby R Ayers; Kyle E Wedin; Ian J Neeland; Ivan S Yuhanna; Daniel R Rader; James A de Lemos; Philip W Shaul Journal: N Engl J Med Date: 2014-11-18 Impact factor: 91.245
Authors: Michelle C Odden; Ira B Tager; Ron T Gansevoort; Stephan J L Bakker; Linda F Fried; Anne B Newman; Ronit Katz; Suzanne Satterfield; Tamara B Harris; Mark J Sarnak; David Siscovick; Michael G Shlipak Journal: Ann Epidemiol Date: 2013-01-10 Impact factor: 3.797
Authors: Ninad S Chaudhary; Hemant K Tiwari; Bertha A Hidalgo; Nita A Limdi; Richard J Reynolds; Mary Cushman; Neil A Zakai; Leslie Lange; Suzanne E Judd; Cheryl A Winkler; Jeffrey B Kopp; Orlando M Gutiérrez; Marguerite R Irvin Journal: Am J Nephrol Date: 2022-01-31 Impact factor: 4.605
Authors: Kelly Roveran Genga; Mark Trinder; HyeJin Julia Kong; Xuan Li; Alex K K Leung; Tadanaga Shimada; Keith R Walley; James A Russell; Gordon A Francis; Liam R Brunham; John H Boyd Journal: Sci Rep Date: 2018-11-13 Impact factor: 4.379
Authors: Zorana Milanović; Jelena Vekić; Vladimir Radonjić; Anja Ilić Božović; Aleksandra Zeljković; Jelena Janac; Vesna Spasojević-Kalimanovska; Jesse Buch; Ramaswamy Chandrashekar; Žanka Bojić-Trbojević; Ljiljana Hajduković; Mary M Christopher; Milica Kovačević Filipović Journal: J Vet Intern Med Date: 2019-06-07 Impact factor: 3.333
Authors: Julio A Lamprea-Montealegre; Robyn L McClelland; James D Otvos; Samia Mora; Manja Koch; Majken K Jensen; Ian H de Boer Journal: J Am Heart Assoc Date: 2019-12-10 Impact factor: 5.501
Authors: Natalya A Blessing; Zhenzhen Wu; Sethu M Madhavan; Jonathan W Choy; Michelle Chen; Myung K Shin; Maarten Hoek; John R Sedor; John F O'Toole; Leslie A Bruggeman Journal: PLoS One Date: 2021-06-17 Impact factor: 3.240