| Literature DB >> 27007772 |
Ji Xi1, Jigui Wang1, Yongle Yu1, Xiaomei Zhang1, Yaping Mao1, Qiang Hou1, Weiquan Liu2.
Abstract
The genome of a highly pathogenic strain of Aleutian disease mink virus (AMDV-BJ) isolated from a domestic farm in North China has been determined and compared with other strains. Alignment analysis of the major structural protein VP2 revealed that AMDV-BJ is unique among 17 other AMDV strains. Compared with the nonpathogenic strain ADV-G, the 3' end Y-shaped hairpin was highly conserved, while a 4-base deletion in the 5' U-shaped terminal palindrome resulted in a different unpaired "bubble" group near the NS1-binding region of the 5' end hairpin which may affect replication efficiency in vivo. We also performed a protein analysis of the NS1, NS2, and new-confirmed NS3 of AMDV-BJ with some related AMDV DNA sequence published, providing information on evolution of AMDV genes. This study shows a useful method to obtain the full-length genome of AMDV and some other parvoviruses.Entities:
Keywords: Aleutian disease mink virus; Full-length genome; Left and right end hairpins; Non-structural proteins NS1/2/3; Structural proteins VP1/2
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Year: 2016 PMID： 27007772 DOI： 10.1007/s11262-016-1320-3
Source DB: PubMed Journal: Virus Genes ISSN： 0920-8569 Impact factor: 2.332