Liat Orenstein1, Angela Chetrit2, Rachel Dankner1,2. 1. a Sackler Faculty of Medicine, School of Public Health , Department of Epidemiology and Preventive Medicine , Tel Aviv University , Ramat Aviv , Tel Aviv , Israel. 2. b The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center , Israel.
Abstract
OBJECTIVES: Investigate associations of healthier behaviors with 30-yr cancer incidence. SUBJECTS/ METHODS: In 1982, 632 healthy men and women (ages 40-70) were interviewed for nutritional habits using a Food Frequency Questionnaire and a 24-h physical activity questionnaire. Blood pressure, weight, and height were measured, and blood was drawn for biochemical profiles. Thirteen and four subjects were excluded due to cancer diagnosis ≤1 yr from recruitment and extreme values of reported total daily calorie intake, respectively. RESULTS: During a mean follow-up of 24.2 yr, 146 cancer incident patients (23.7%) were documented. Total cancer risk was 38% lower in the medium vegetable intake tertile [adjusted hazards ratio (HR) = 0.62, 95%confidence interval (CI): 0.40-0.95], and 66% higher in the medium fruit intake tertile (adjusted HR = 1.66, 95%CI: 1.08-2.55) compared to the lowest tertile. The risk of gastrointestinal cancers was 3 times greater for the highest, compared to the lowest, dairy consumption tertile (HR = 3.06, 95%CI: 1.01-9.23). "Healthy lifestyle" (normal BMI, never smoked, consuming high levels of dietary fiber and vegetables, and more physically active) reduced overall cancer risk (adjusted HR = 0.63, 95%CI: 0.44-0.91) as compared to the rest of the cohort. CONCLUSIONS: Our findings reinforce the importance of lifestyle-related factors, which are relatively low-cost and may contribute to reduction in the burden of malignant diseases.
OBJECTIVES: Investigate associations of healthier behaviors with 30-yr cancer incidence. SUBJECTS/ METHODS: In 1982, 632 healthy men and women (ages 40-70) were interviewed for nutritional habits using a Food Frequency Questionnaire and a 24-h physical activity questionnaire. Blood pressure, weight, and height were measured, and blood was drawn for biochemical profiles. Thirteen and four subjects were excluded due to cancer diagnosis ≤1 yr from recruitment and extreme values of reported total daily calorie intake, respectively. RESULTS: During a mean follow-up of 24.2 yr, 146 cancer incident patients (23.7%) were documented. Total cancer risk was 38% lower in the medium vegetable intake tertile [adjusted hazards ratio (HR) = 0.62, 95%confidence interval (CI): 0.40-0.95], and 66% higher in the medium fruit intake tertile (adjusted HR = 1.66, 95%CI: 1.08-2.55) compared to the lowest tertile. The risk of gastrointestinal cancers was 3 times greater for the highest, compared to the lowest, dairy consumption tertile (HR = 3.06, 95%CI: 1.01-9.23). "Healthy lifestyle" (normal BMI, never smoked, consuming high levels of dietary fiber and vegetables, and more physically active) reduced overall cancer risk (adjusted HR = 0.63, 95%CI: 0.44-0.91) as compared to the rest of the cohort. CONCLUSIONS: Our findings reinforce the importance of lifestyle-related factors, which are relatively low-cost and may contribute to reduction in the burden of malignant diseases.
Authors: Linda C Tapsell; Maureen Lonergan; Marijka J Batterham; Elizabeth P Neale; Allison Martin; Rebecca Thorne; Frank Deane; Gregory Peoples Journal: BMJ Open Date: 2017-07-13 Impact factor: 2.692
Authors: Dagfinn Aune; Edward Giovannucci; Paolo Boffetta; Lars T Fadnes; NaNa Keum; Teresa Norat; Darren C Greenwood; Elio Riboli; Lars J Vatten; Serena Tonstad Journal: Int J Epidemiol Date: 2017-06-01 Impact factor: 7.196