| Literature DB >> 27006231 |
Gabriel Dasilva1, Manuel Pazos2, Eduardo García-Egido2, Jara Pérez-Jiménez3, Josep Lluis Torres3, Montserrat Giralt4, María-Rosa Nogués4, Isabel Medina2.
Abstract
The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS.Entities:
Keywords: DHA; EPA; Inflammation; Lipid mediators; Metabolic Syndrome; Oxidative stress; SHROB
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Year: 2016 PMID： 27006231 DOI： 10.1016/j.foodchem.2016.03.020
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514