| Literature DB >> 27005804 |
Emile Mehanna1,2, Anne Hamik1,3,2, Richard A Josephson4,5.
Abstract
Historically, the relationship between exercise and the cardiovascular system was viewed as unidirectional, with a disease resulting in exercise limitation and hazard. This article reviews and explores the bidirectional nature, delineating the effects, generally positive, on the cardiovascular system and atherosclerosis. Exercise augments eNOS, affects redox potential, and favorably affects mediators of atherosclerosis including lipids, glucose homeostasis, and inflammation. There are direct effects on the vasculature as well as indirect benefits related to exercise-induced changes in body composition and skeletal muscle. Application of aerobic exercise to specific populations is described, with the hope that this knowledge will move the science forward and improve individual patient outcome.Entities:
Keywords: Cardiac rehabilitation; Cardiorespiratory fitness; Cardiovascular disease prevention; Exercise; eNOS
Mesh:
Year: 2016 PMID: 27005804 PMCID: PMC5593139 DOI: 10.1007/s11883-016-0580-7
Source DB: PubMed Journal: Curr Atheroscler Rep ISSN: 1523-3804 Impact factor: 5.113