Literature DB >> 27005438

The 5-Lipoxygenase as modulator of Alzheimer's γ-secretase and therapeutic target.

Jin Chu1, Domenico Praticò2.   

Abstract

Alzheimer's disease (AD) is an age-related, neurodegenerative disorder characterized by cognitive impairment with memory loss, extracellular amyloid beta (Aβ) peptides aggregation, and intracellular hyper-phosphorylated tau neurofibrillary tangles (NFT) accumulation. Although the 5-lipoxygenase (5LO) protein enzyme is well known as an important modulators of oxidation and inflammation, recent work has highlighted the new hypothesis that this pathway may play a direct role in AD pathogenesis. In this review article, we will discuss how the 5LO via the γ-secretase influences Aβ peptides formation, and other molecular pathologies including neuroinflammation, synaptic integrity, and cognitive functions, and provide an assessment of how targeting this protein could lead to novel therapeutics for AD and other related neurodegenerative disorders.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  5-lipoxygenase; Alzheimer’s disease; Amyloid beta; γ-Secretase; γ-Secretase activating protein

Mesh：

Substances：

Year:  2016        PMID： 27005438      PMCID： PMC5028246          DOI： 10.1016/j.brainresbull.2016.03.010

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  44 in total

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Authors:  D Paris; T Town; T A Parker; J Tan; J Humphrey; F Crawford; M Mullan
Journal:  Exp Neurol       Date:  1999-05       Impact factor: 5.330

2.  5-Lipoxygenase (5-LOX) promoter polymorphism in patients with early-onset and late-onset Alzheimer's disease.

Authors:  T Qu; R Manev; H Manev
Journal:  J Neuropsychiatry Clin Neurosci       Date:  2001       Impact factor: 2.198

3.  A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

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Journal:  Nature       Date:  2012-08-02       Impact factor: 49.962

4.  The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old.

Authors:  Cinzia M Chinnici; Yuemang Yao; Domenico Praticò
Journal:  Neurobiol Aging       Date:  2006-08-22       Impact factor: 4.673

Review 5.  Cysteinyl leukotrienes and their receptors: molecular and functional characteristics.

Authors:  R K Singh; S Gupta; S Dastidar; A Ray
Journal:  Pharmacology       Date:  2010-06-02       Impact factor: 2.547

6.  Leukotrienes and inflammation

Authors: 
Journal:  Am J Respir Crit Care Med       Date:  1998-06       Impact factor: 21.405

7.  Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.

Authors:  Gen He; Wenjie Luo; Peng Li; Christine Remmers; William J Netzer; Joseph Hendrick; Karima Bettayeb; Marc Flajolet; Fred Gorelick; Lawrence P Wennogle; Paul Greengard
Journal:  Nature       Date:  2010-09-02       Impact factor: 49.962

Review 8.  Oxidative stress hypothesis in Alzheimer's disease: a reappraisal.

Authors:  Domenico Praticò
Journal:  Trends Pharmacol Sci       Date:  2008-10-04       Impact factor: 14.819

9.  Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence.

Authors:  Jin Chu; Jian-Guo Li; Nicholas E Hoffman; Alexandra M Stough; Muniswamy Madesh; Domenico Praticò
Journal:  Sci Rep       Date:  2015-06-16       Impact factor: 4.379

10.  Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.

Authors:  Julia Marschallinger; Iris Schäffner; Barbara Klein; Renate Gelfert; Francisco J Rivera; Sebastian Illes; Lukas Grassner; Maximilian Janssen; Peter Rotheneichner; Claudia Schmuckermair; Roland Coras; Marta Boccazzi; Mansoor Chishty; Florian B Lagler; Marija Renic; Hans-Christian Bauer; Nicolas Singewald; Ingmar Blümcke; Ulrich Bogdahn; Sebastien Couillard-Despres; D Chichung Lie; Maria P Abbracchio; Ludwig Aigner
Journal:  Nat Commun       Date:  2015-10-27       Impact factor: 14.919
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  9 in total

1.  Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy.

Authors:  Phillip F Giannopoulos; Domenico Praticò
Journal:  Mol Neurobiol       Date:  2017-11-11       Impact factor: 5.590

Review 2.  Leukotriene biosynthetic enzymes as therapeutic targets.

Authors:  Jesper Z Haeggström
Journal:  J Clin Invest       Date:  2018-07-02       Impact factor: 14.808

3.  Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins.

Authors:  Srikant Rangaraju; Eric B Dammer; Syed Ali Raza; Tianwen Gao; Hailian Xiao; Ranjita Betarbet; Duc M Duong; James A Webster; Chadwick M Hales; James J Lah; Allan I Levey; Nicholas T Seyfried
Journal:  Mol Neurodegener       Date:  2018-06-28       Impact factor: 14.195

Review 4.  Inflammation: the link between comorbidities, genetics, and Alzheimer's disease.

Authors:  Estella A Newcombe; Judith Camats-Perna; Mallone L Silva; Nicholas Valmas; Tee Jong Huat; Rodrigo Medeiros
Journal:  J Neuroinflammation       Date:  2018-09-24       Impact factor: 8.322

Review 5.  The Role of Eicosanoids in Alzheimer's Disease.

Authors:  Roger G Biringer
Journal:  Int J Environ Res Public Health       Date:  2019-07-18       Impact factor: 3.390

6.  New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition.

Authors:  Audrey Isabel Chiasson; Samuel Robichaud; Fanta J Ndongou Moutombi; Mathieu P A Hébert; Maroua Mbarik; Marc E Surette; Mohamed Touaibia
Journal:  Molecules       Date:  2020-10-14       Impact factor: 4.411

Review 7.  Recent Trends in the Management of Alzheimer's Disease: Current Therapeutic Options and Drug Repurposing Approaches.

Authors:  Rakesh K Singh
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363

8.  Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice.

Authors:  Phillip F Giannopoulos; Jian Chiu; Domenico Praticò
Journal:  Aging Cell       Date:  2018-04-01       Impact factor: 9.304

9.  Thyme essential oils from Spain: Aromatic profile ascertained by GC-MS, and their antioxidant, anti-lipoxygenase and antimicrobial activities.

Authors:  Ana-Belen Cutillas; Alejandro Carrasco; Ramiro Martinez-Gutierrez; Virginia Tomas; Jose Tudela
Journal:  J Food Drug Anal       Date:  2017-06-15       Impact factor: 6.157
  9 in total

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