Literature DB >> 27004010

Liuweiwuling tablets protect against acetaminophen hepatotoxicity: What is the protective mechanism?

Kuo Du1, Hartmut Jaeschke1.   

Abstract

Study of the effects of natural products, including traditional Chinese Medicines, on acetaminophen hepatotoxicity has gained considerable popularity in recent years, and some of them showed positive results and even promising therapeutic potentials. A recent report suggested that Liuweiwuling tablets protect against acetaminophen hepatotoxicity and promote liver regeneration in a rodent model through alleviating the inflammatory response. However, several concerns exist regarding the limitations of the experimental design and interpretation of the data presented in this manuscript.

Entities:  

Keywords:  Acetaminophen hepatotoxicity; Liuweiwuling; Liver regeneration; Natural products; Sterile inflammation

Mesh：

Substances：

Year:  2016        PMID： 27004010      PMCID： PMC4790008          DOI： 10.3748/wjg.v22.i11.3302

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  25 in total

1.  Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.

Authors:  Clarence David Williams; Mary Lynn Bajt; Anwar Farhood; Hartmut Jaeschke
Journal:  Liver Int       Date:  2010-10       Impact factor: 5.828

2.  RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.

Authors:  Daniel J Antoine; Rosalind E Jenkins; James W Dear; Dominic P Williams; Mitchell R McGill; Matthew R Sharpe; Darren G Craig; Kenneth J Simpson; Hartmut Jaeschke; B Kevin Park
Journal:  J Hepatol       Date:  2012-01-17       Impact factor: 25.083

Review 3.  Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity.

Authors:  Hartmut Jaeschke; C David Williams; Anup Ramachandran; Mary L Bajt
Journal:  Liver Int       Date:  2011-03-14       Impact factor: 5.828

4.  The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.

Authors:  Kuo Du; C David Williams; Mitchell R McGill; Yuchao Xie; Anwar Farhood; Mathieu Vinken; Hartmut Jaeschke
Journal:  Toxicol Appl Pharmacol       Date:  2013-09-23       Impact factor: 4.219

Review 5.  Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

Authors:  Hartmut Jaeschke; Mitchell R McGill; C David Williams; Anup Ramachandran
Journal:  Life Sci       Date:  2011-02-04       Impact factor: 5.037

Review 6.  Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.

Authors:  Hartmut Jaeschke; Mitchell R McGill; Anup Ramachandran
Journal:  Drug Metab Rev       Date:  2012-01-10       Impact factor: 4.518

7.  Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury.

Authors:  C David Williams; Daniel J Antoine; Patrick J Shaw; Craig Benson; Anwar Farhood; Dominic P Williams; Thirumala-Devi Kanneganti; B Kevin Park; Hartmut Jaeschke
Journal:  Toxicol Appl Pharmacol       Date:  2011-03-21       Impact factor: 4.219

Review 8.  Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.

Authors:  Hartmut Jaeschke; C David Williams; Mitchell R McGill; Yuchao Xie; Anup Ramachandran
Journal:  Food Chem Toxicol       Date:  2013-01-22       Impact factor: 6.023

9.  Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.

Authors:  Yuchao Xie; C David Williams; Mitchell R McGill; Margitta Lebofsky; Anup Ramachandran; Hartmut Jaeschke
Journal:  Toxicol Sci       Date:  2012-09-17       Impact factor: 4.849

10.  Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity.

Authors:  Runkuan Yang; Shutian Zhang; Henri Kajander; Shengtao Zhu; Marja-Leena Koskinen; Jyrki Tenhunen
Journal:  BMC Gastroenterol       Date:  2011-11-15       Impact factor: 3.067
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  5 in total

Review 1.  Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure.

Authors:  Benjamin L Woolbright; Hartmut Jaeschke
Journal:  J Hepatol       Date:  2016-11-29       Impact factor: 25.083

2.  A systems pharmacology-oriented discovery of a new therapeutic use of the TCM formula Liuweiwuling for liver failure.

Authors:  Jia-Bo Wang; He-Rong Cui; Rui-Lin Wang; Cong-En Zhang; Ming Niu; Zhao-Fang Bai; Gen-Hua Xu; Peng-Yan Li; Wen-Yan Jiang; Jing-Jing Han; Xiao Ma; Guang-Ming Cai; Rui-Sheng Li; Li-Ping Zhang; Xiao-He Xiao
Journal:  Sci Rep       Date:  2018-04-04       Impact factor: 4.379

3.  Post-treatment with glycyrrhizin can attenuate hepatic mitochondrial damage induced by acetaminophen in mice.

Authors:  Xue-Liang Dang; Long-Fei Yang; Lei Shi; Long-Fei Li; Ping He; Jie Chen; Bei-Jie Zheng; Peng Yang; Ai-Dong Wen
Journal:  Exp Biol Med (Maywood)       Date:  2020-12-20

4.  The Combination of Schisandrol B and Wedelolactone Synergistically Reverses Hepatic Fibrosis Via Modulating Multiple Signaling Pathways in Mice.

Authors:  Yongqiang Ai; Wei Shi; Xiaobin Zuo; Xiaoming Sun; Yuanyuan Chen; Zhilei Wang; Ruisheng Li; Xueai Song; Wenzhang Dai; Wenqing Mu; Kaixin Ding; Zhiyong Li; Qiang Li; Xiaohe Xiao; Xiaoyan Zhan; Zhaofang Bai
Journal:  Front Pharmacol       Date:  2021-06-03       Impact factor: 5.810

5.  Effect of Liuweiwuling tablet on biochemical and virological parameters, and quality of life in patients with hepatitis B virus-related cirrhosis: A protocol for a systematic review and meta-analysis.

Authors:  Ding Li; Min Zhu; Changhui Zhou; Xiujing Liu
Journal:  Medicine (Baltimore)       Date:  2020-09-11       Impact factor: 1.817
  5 in total

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