Alexandre Yazigi1, Aurelia Eldin De Pecoulas1, Christelle Vauloup-Fellous2, Liliane Grangeot-Keros2, Jean-Marc Ayoubi1,3, Olivier Picone1,3. 1. a Department of Obstetrics and Gynecology , Hôpital Foch , Suresnes , France. 2. b AP-HP, Hôpital Paul Brousse, Groupe Hospitalier Universitaire Paris-Sud, Virologie, WHO Rubella NRL, National Reference Laboratory for Maternofetal Rubella Infections, Univ Paris-Sud , INSERM U1193, Villejuif , France , and. 3. c EA2493; UFR Des Sciences De La Santé Simone Veil, Université Versailles Saint Quentin En Yvelines , Montigny Le Bretonneux , France.
Abstract
OBJECTIVE: Rubella virus infection during the first trimester of pregnancy can cause congenital rubella syndrome (CRS). We aimed to describe the abnormalities in order to define the ultrasound features to look for when performing prenatal scans. The goal of this review is to focus specifically on the signs of CRS accessible to prenatal diagnosis. METHODS: We analyzed every case of CRS described before and/or after birth that we identified in the Pubmed database and classified them as accessible or not to prenatal diagnosis. RESULTS: The most frequently reported malformations accessible to prenatal diagnosis were: cardiac septal defects, pulmonary artery stenosis, microcephaly, cataract, microphtalmia, and hepatosplenomegaly. CONCLUSION: This extensive literature review shows that the ultrasound features of CRS are not well known, even though rubella was the first teratogenic virus described. This review will help clinicians in the management of rubella during pregnancy by clarifying the findings to be sought.
OBJECTIVE:Rubella virus infection during the first trimester of pregnancy can cause congenital rubella syndrome (CRS). We aimed to describe the abnormalities in order to define the ultrasound features to look for when performing prenatal scans. The goal of this review is to focus specifically on the signs of CRS accessible to prenatal diagnosis. METHODS: We analyzed every case of CRS described before and/or after birth that we identified in the Pubmed database and classified them as accessible or not to prenatal diagnosis. RESULTS: The most frequently reported malformations accessible to prenatal diagnosis were: cardiac septal defects, pulmonary artery stenosis, microcephaly, cataract, microphtalmia, and hepatosplenomegaly. CONCLUSION: This extensive literature review shows that the ultrasound features of CRS are not well known, even though rubella was the first teratogenic virus described. This review will help clinicians in the management of rubella during pregnancy by clarifying the findings to be sought.
Authors: Benjamin J S Al-Haddad; Elizabeth Oler; Blair Armistead; Nada A Elsayed; Daniel R Weinberger; Raphael Bernier; Irina Burd; Raj Kapur; Bo Jacobsson; Caihong Wang; Indira Mysorekar; Lakshmi Rajagopal; Kristina M Adams Waldorf Journal: Am J Obstet Gynecol Date: 2019-06-15 Impact factor: 8.661
Authors: Phillipe Boeuf; Heidi E Drummer; Jack S Richards; Michelle J L Scoullar; James G Beeson Journal: BMC Med Date: 2016-08-03 Impact factor: 8.775
Authors: Sabrina Gabriele Maia Oliveira Rocha; Luciano Lima Correia; Antônio José Lêdo Alves Da Cunha; Hermano Alexandre Lima Rocha; Álvaro Jorge Madeiro Leite; Jocileide Sales Campos; Tereza de Jesus Pinheiro Gomes Bandeira; Lucas Silveira Do Nascimento; Anamaria Cavalcante E Silva Journal: Ann Glob Health Date: 2019-08-28 Impact factor: 2.462
Authors: Tulika Singh; Claire E Otero; Katherine Li; Sarah M Valencia; Ashley N Nelson; Sallie R Permar Journal: Front Pediatr Date: 2020-12-15 Impact factor: 3.418
Authors: Vipul Sharma; Lisa S Goessling; Anoop K Brar; Chetanchandra S Joshi; Indira U Mysorekar; Pirooz Eghtesady Journal: J Am Heart Assoc Date: 2021-01-14 Impact factor: 5.501
Authors: Philippa Harding; Maria Toms; Elena Schiff; Nicholas Owen; Suzannah Bell; Ian Christopher Lloyd; Mariya Moosajee Journal: Int J Mol Sci Date: 2021-02-22 Impact factor: 5.923