| Literature DB >> 27002401 |
Ignacio Pérez-Victoria1, Jesús Martín1, Fernando Reyes1.
Abstract
Drug discovery from marine natural products has experienced a revival since the beginning of this century. To be successful in this field, rapid dereplication (identification of already known bioactive compounds) is essential in order to assess the chemical novelty of crude extracts and their fractions. Access to the appropriate state-of-the-art analytical instrumentation and to suitable databases is a fundamental requirement in such a task. A brief survey of the most robust LC/UV/MS- and NMR-based approaches employed for marine natural product dereplication is presented alongside a description of the procedures followed to achieve this goal in our research group. Georg Thieme Verlag KG Stuttgart · New York.Entities:
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Year: 2016 PMID： 27002401 DOI： 10.1055/s-0042-101763
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352