Eita Goto1. 1. a Department of Medicine and Public Health , Nagoya Medical Science Research Institute , Nagoya , Japan.
Abstract
OBJECTIVE: This study was performed to determine the dose-response relationships between maternal anthropometric variables and risk of small for gestational age (SGA). METHODS: Linear and nonlinear dose-response meta-analyses were performed to summarize the adjusted relative risks of SGA. Ten databases, including PubMed (MEDLINE), were searched. Study quality was assessed using the Newcastle-Ottawa scale. RESULTS: A total of 323 243 subjects were extracted from high-quality studies to evaluate maternal body mass index (BMI) (n = 9). The generalizability of the findings regarding height and weight (n = 3 and 2, respectively) was limited. The non-linear model (p for non-linearity < 0.05) showed a significant and inverse association of maternal BMI with risk of SGA, although only two of nine studies involved obese women (i.e. BMI ≥ 30 kg/m2). The slope of the dose-response curve between maternal BMI and SGA (i.e. the amount of reduction in SGA risk) decreased gradually. CONCLUSIONS: SGA risk may be reduced by increasing BMI of normal (i.e. 18.5 kg/m2 ≤ BMI < 25 kg/m2) and overweight women (i.e. 25 kg/m2 ≤ BMI < 30 kg/m2), but the most marked reduction is achieved by increasing BMI of underweight women (i.e. BMI < 18.5 kg/m2).
OBJECTIVE: This study was performed to determine the dose-response relationships between maternal anthropometric variables and risk of small for gestational age (SGA). METHODS: Linear and nonlinear dose-response meta-analyses were performed to summarize the adjusted relative risks of SGA. Ten databases, including PubMed (MEDLINE), were searched. Study quality was assessed using the Newcastle-Ottawa scale. RESULTS: A total of 323 243 subjects were extracted from high-quality studies to evaluate maternal body mass index (BMI) (n = 9). The generalizability of the findings regarding height and weight (n = 3 and 2, respectively) was limited. The non-linear model (p for non-linearity < 0.05) showed a significant and inverse association of maternal BMI with risk of SGA, although only two of nine studies involved obesewomen (i.e. BMI ≥ 30 kg/m2). The slope of the dose-response curve between maternal BMI and SGA (i.e. the amount of reduction in SGA risk) decreased gradually. CONCLUSIONS: SGA risk may be reduced by increasing BMI of normal (i.e. 18.5 kg/m2 ≤ BMI < 25 kg/m2) and overweight women (i.e. 25 kg/m2 ≤ BMI < 30 kg/m2), but the most marked reduction is achieved by increasing BMI of underweight women (i.e. BMI < 18.5 kg/m2).
Entities:
Keywords:
Anthropometry; body mass index; meta-analysis; risk; small for gestational age
Authors: Jamie L Dorsey; Swetha Manohar; Sumanta Neupane; Binod Shrestha; Rolf D W Klemm; Keith P West Journal: Matern Child Nutr Date: 2017-02-23 Impact factor: 3.092