| Literature DB >> 27001850 |
Thomas H Meek1, Jarrell T Nelson1, Miles E Matsen1, Mauricio D Dorfman1, Stephan J Guyenet1, Vincent Damian1, Margaret B Allison2, Jarrad M Scarlett1, Hong T Nguyen1, Joshua P Thaler1, David P Olson2, Martin G Myers3, Michael W Schwartz1, Gregory J Morton4.
Abstract
Previous studies implicate the hypothalamic ventromedial nucleus (VMN) in glycemic control. Here, we report that selective inhibition of the subset of VMN neurons that express the transcription factor steroidogenic-factor 1 (VMN(SF1) neurons) blocks recovery from insulin-induced hypoglycemia whereas, conversely, activation of VMN(SF1) neurons causes diabetes-range hyperglycemia. Moreover, this hyperglycemic response is reproduced by selective activation of VMN(SF1) fibers projecting to the anterior bed nucleus of the stria terminalis (aBNST), but not to other brain areas innervated by VMN(SF1) neurons. We also report that neurons in the lateral parabrachial nucleus (LPBN), a brain area that is also implicated in the response to hypoglycemia, make synaptic connections with the specific subset of glucoregulatory VMN(SF1) neurons that project to the aBNST. These results collectively establish a physiological role in glucose homeostasis for VMN(SF1) neurons and suggest that these neurons are part of an ascending glucoregulatory LPBN→VMN(SF1)→aBNST neurocircuit.Entities:
Keywords: bed nucleus of the stria terminalis; counter regulation; glucoregulatory circuit; hyperglycemia; ventromedial nucleus
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Year: 2016 PMID： 27001850 PMCID： PMC4833243 DOI： 10.1073/pnas.1521160113
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205