Literature DB >> 27001745

Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer.

Mohammad Mahdi Hasani-Sadrabadi1, Shahrouz Taranejoo2,3, Erfan Dashtimoghadam4, Ghasem Bahlakeh5, Fatemeh Sadat Majedi6, Jules John VanDersarl7, Mohsen Janmaleki8, Fatemeh Sharifi9, Arnaud Bertsch7, Kerry Hourigan2,3, Lobat Tayebi4,10, Philippe Renaud7, Karl I Jacob1.   

Abstract

A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cancer therapy; core-shell nanoparticles; drug delivery; microfluidics platform; stimuli-responsive release

Mesh：

Substances：

Year:  2016        PMID： 27001745     DOI： 10.1002/adma.201502697

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  9 in total

1.  Cytokine Secreting Microparticles Engineer the Fate and the Effector Functions of T-Cells.

Authors:  Fatemeh S Majedi; Mohammad Mahdi Hasani-Sadrabadi; Yoko Kidani; Timothy J Thauland; Alireza Moshaverinia; Manish J Butte; Steven J Bensinger; Louis-S Bouchard
Journal:  Adv Mater       Date:  2018-01-08       Impact factor: 30.849

2.  Augmenting T-cell responses to tumors by in situ nanomanufacturing.

Authors:  Mohammad Mahdi Hasani-Sadrabadi; Fatemeh S Majedi; Matthew L Miller; Timothy J Thauland; Louis-S Bouchard; Song Li; Manish J Butte
Journal:  Mater Horiz       Date:  2020-09-29       Impact factor: 13.266

3.  Polyserotonin Nanoparticles as Multifunctional Materials for Biomedical Applications.

Authors:  Nako Nakatsuka; Mohammad Mahdi Hasani-Sadrabadi; Kevin M Cheung; Thomas D Young; Ghasem Bahlakeh; Alireza Moshaverinia; Paul S Weiss; Anne M Andrews
Journal:  ACS Nano       Date:  2018-04-30       Impact factor: 15.881

4.  Fabrication of tunable, high-molecular-weight polymeric nanoparticles via ultrafast acoustofluidic micromixing.

Authors:  Shuaiguo Zhao; Po-Hsun Huang; Heying Zhang; Joseph Rich; Hunter Bachman; Jennifer Ye; Wenfen Zhang; Chuyi Chen; Zhemiao Xie; Zhenhua Tian; Putong Kang; Hai Fu; Tony Jun Huang
Journal:  Lab Chip       Date:  2021-06-15       Impact factor: 7.517

Review 5.  Micro and nanoscale technologies in oral drug delivery.

Authors:  Samad Ahadian; Joel A Finbloom; Mohammad Mofidfar; Sibel Emir Diltemiz; Fatemeh Nasrollahi; Elham Davoodi; Vahid Hosseini; Ioanna Mylonaki; Sivakoti Sangabathuni; Hossein Montazerian; Kirsten Fetah; Rohollah Nasiri; Mehmet Remzi Dokmeci; Molly M Stevens; Tejal A Desai; Ali Khademhosseini
Journal:  Adv Drug Deliv Rev       Date:  2020-07-22       Impact factor: 15.470

6.  Adjudin-loaded redox-sensitive paclitaxel-prodrug micelles for overcoming multidrug resistance with efficient targeted Colon cancer therapy.

Authors:  Deli Chen; Sitang Ge; Lugen Zuo; Shuanhu Wang; Mulin Liu; Shiqing Li
Journal:  Drug Deliv       Date:  2020-12       Impact factor: 6.419

Review 7.  Microfluidics for core-shell drug carrier particles - a review.

Authors:  Sepideh Yazdian Kashani; Amir Afzalian; Farbod Shirinichi; Mostafa Keshavarz Moraveji
Journal:  RSC Adv       Date:  2020-12-23       Impact factor: 3.361

8.  Comparison of Physicochemical Properties of LipoParticles as mRNA Carrier Prepared by Automated Microfluidic System and Bulk Method.

Authors:  Camille Ayad; Altan Yavuz; Jean-Paul Salvi; Pierre Libeau; Jean-Yves Exposito; Valentine Ginet; Claire Monge; Bernard Verrier; Danielle Campiol Arruda
Journal:  Pharmaceutics       Date:  2022-06-18       Impact factor: 6.525

Review 9.  Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer.

Authors:  Yu Guo; Min Wang; Yongbo Zou; Longhai Jin; Zeyun Zhao; Qi Liu; Shuang Wang; Jiannan Li
Journal:  J Nanobiotechnology       Date:  2022-08-11       Impact factor: 9.429
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.