| Literature DB >> 27000493 |
Erik Vrij1, Jeroen Rouwkema2, Vanessa LaPointe1, Clemens van Blitterswijk1, Roman Truckenmüller1, Nicolas Rivron1,3.
Abstract
Material-free tissues are assembled using solely cells. Microstructured hydrogel templates and high content screening allow the formation of centimeter-scale tissues with precise architectures. Similar to developing tissues, these contract autonomously, controllably shift shape, self-scaffold by secreting extracellular matrix, and undergo morphogenesis.Keywords: bottom-up tissue engineering; cellular building blocks; directed development; high-throughput screening; tissues
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Year: 2016 PMID: 27000493 DOI: 10.1002/adma.201505723
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849