AIM: The association between Lipoprotein (a) (Lp [a]) and common carotid intima media thickness (IMT) has been evaluated in 222 menopausal women. MATERIAL & METHODS: Lp (a) and IMT were measured, carotid ultrasound examination (B-Mode imaging) was performed and mean max IMT was calculated. RESULTS: Lp (a) was significantly lower in women with metabolic syndrome (MS). In a multivariate analysis Lp (a) showed the following odds ratio (OR; all p < 0.05) of having common carotid IMT (≥1.30 mm): 1.03, adjusted for age, low-density lipoprotein cholesterol (LDL) and waist circumference; 1.02, adjusted for age LDL, homeostatic assessment model (HOMA). In women without MS, after controlling for age, LDL and waist circumference, we found the following OR for increased IMT (≥1.30; OR: 1.03; for Lp [a]); 1.02 adjusted for age, LDL and HOMA (all p < 0.05). In women with MS these relationships were not statistically significant. CONCLUSION: Lp (a) gives additional information in the risk assessment for atherosclerotic cardiovascular disease, especially in menopausal women without MS.
AIM: The association between Lipoprotein (a) (Lp [a]) and common carotid intima media thickness (IMT) has been evaluated in 222 menopausal women. MATERIAL & METHODS:Lp (a) and IMT were measured, carotid ultrasound examination (B-Mode imaging) was performed and mean max IMT was calculated. RESULTS:Lp (a) was significantly lower in women with metabolic syndrome (MS). In a multivariate analysis Lp (a) showed the following odds ratio (OR; all p < 0.05) of having common carotid IMT (≥1.30 mm): 1.03, adjusted for age, low-density lipoprotein cholesterol (LDL) and waist circumference; 1.02, adjusted for age LDL, homeostatic assessment model (HOMA). In women without MS, after controlling for age, LDL and waist circumference, we found the following OR for increased IMT (≥1.30; OR: 1.03; for Lp [a]); 1.02 adjusted for age, LDL and HOMA (all p < 0.05). In women with MS these relationships were not statistically significant. CONCLUSION:Lp (a) gives additional information in the risk assessment for atherosclerotic cardiovascular disease, especially in menopausal women without MS.
Entities:
Keywords:
Lp (a); atherosclerosis; cardiovascular risk; metabolic syndrome; ultrasound; women
Authors: Nikolaus Buchmann; Till Ittermann; Ilja Demuth; Marcello R P Markus; Henry Völzke; Marcus Dörr; Nele Friedrich; Markus M Lerch; Raul D Santos; Sabine Schipf; Elisabeth Steinhagen-Thiessen Journal: Dtsch Arztebl Int Date: 2022-04-15 Impact factor: 8.251
Authors: Marco Gentile; Arcangelo Iannuzzi; Francesco Giallauria; Antonello D'Andrea; Elio Venturini; Mario Pacileo; Giuseppe Covetti; Camilla Panico; Amalia Mattiello; Giuseppe Vitale; Filippo Maria Sarullo; Paolo Rubba; Carlo Vigorito; Salvatore Panico; Gabriella Iannuzzo Journal: J Clin Med Date: 2020-05-11 Impact factor: 4.964
Authors: Arcangelo Iannuzzi; Paolo Rubba; Marco Gentile; Vania Mallardo; Ilenia Calcaterra; Alessandro Bresciani; Giuseppe Covetti; Gianluigi Cuomo; Pasquale Merone; Anna Di Lorenzo; Roberta Alfieri; Emilio Aliberti; Francesco Giallauria; Matteo Nicola Dario Di Minno; Gabriella Iannuzzo Journal: Biomedicines Date: 2021-05-06