Literature DB >> 26999420

Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus.

Nor Bahirah Kasim1, Hasniza Zaman Huri1,2, Shireene Ratna Vethakkan3, Luqman Ibrahim3, Bashar Mudhaffar Abdullah2.   

Abstract

Generally, obese and overweight individuals display higher free fatty acid levels, which stimulate insulin resistance. The combination of overweight or obesity with insulin resistance can trigger Type 2 diabetes mellitus (T2DM) and are primary contributing factors to the development of uncontrolled T2DM. Genetic polymorphisms also play an important role as they can impact a population's susceptibility to becoming overweight or obese and developing related chronic complications, such as uncontrolled T2DM. This review specifically examines the genetic polymorphisms associated with overweight and obesity in patients with uncontrolled T2DM. Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.

Entities:  

Keywords:  ADIPOQ; GRB14; IRS2; LEPR; PPARG; genetic polymorphisms; insulin resistance; obesity; overweight; uncontrolled T2DM

Mesh：

Substances：

Year:  2016        PMID： 26999420     DOI： 10.2217/bmm-2015-0037

Source DB:  PubMed          Journal:  Biomark Med        ISSN： 1752-0363            Impact factor:   2.851


  11 in total

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