| Literature DB >> 26998813 |
Yang Liu1,2, Yinjun Xie1, Hongli Wang1, Hanmin Huang1.
Abstract
A novel highly enantioselective aminomethylamination of conjugated dienes with aminals catalyzed by a chiral palladium complex ligated with BINOL-derived chiral diphosphinite has been successfully developed. This reaction proceeds via a Pd-catalyzed cascade C-N bond activation, aminomethylation, and asymmetric allylic amination reaction under mild reaction conditions, providing a unique and efficient strategy for the synthesis of enantiomerically pure allylic 1,3-diamines.Entities:
Year: 2016 PMID： 26998813 DOI： 10.1021/jacs.6b00976
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419