Yang Liu1,2, Yinjun Xie1, Hongli Wang1, Hanmin Huang1. 1. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, P. R. China. 2. University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
Abstract
A novel highly enantioselective aminomethylamination of conjugated dienes with aminals catalyzed by a chiral palladium complex ligated with BINOL-derived chiral diphosphinite has been successfully developed. This reaction proceeds via a Pd-catalyzed cascade C-N bond activation, aminomethylation, and asymmetric allylic amination reaction under mild reaction conditions, providing a unique and efficient strategy for the synthesis of enantiomerically pure allylic 1,3-diamines.
A novel highly enantioselective aminomethylamination of conjugated dienes with aminals catalyzed by a chiral n class="Chemical">palladium complex ligated with BINOL-derived chiral diphosphinite has been successfully developed. This reaction proceeds via a Pd-catalyzed cascade C-N bond activation, aminomethylation, and asymmetric allylic amination reaction under mild reaction conditions, providing a unique and efficient strategy for the synthesis of enantiomerically pure allylic 1,3-diamines.
Authors: Hui Zhou; Hetti Handi Chaminda Lakmal; Jonathan M Baine; Henry U Valle; Xue Xu; Xin Cui Journal: Chem Sci Date: 2017-07-24 Impact factor: 9.825