| Literature DB >> 26998024 |
Zijian Wang1, Wei Xiong1, Cizhong Pan1, Liang Zhu1, Xinjun Wang1, Zhichao Huang1, Xiaokun Zhao1, Zhaohui Zhong1.
Abstract
The present study reports an unusual case of high-grade bladder cancer in a 10-year-old girl who complained of painless hematuria and urinary frequency. The tumor displayed sarcomatoid differentiation and an aggressive behavior, which required the administration of adjuvant chemotherapy. However, the disease progressed and the patient succumbed 6 months after surgery. It is known that the majority of malignant bladder cancers in pediatric patients are low-grade and present at an early stage, whereas sarcomatoid differentiation in the setting of a high-grade urothelial carcinoma is indicative of a poor prognosis. It is important that gross hematuria in pediatric patients is investigated carefully. It is recommended that the management of urothelial neoplasia in young patients should be predominantly decided on the basis of the grade and stage of the tumor rather than the age of the patient.Entities:
Keywords: adjuvant therapy; bladder cancer; children; radical cystectomy
Year: 2016 PMID： 26998024 PMCID： PMC4774393 DOI： 10.3892/etm.2016.3012
Source DB: PubMed Journal: Exp Ther Med ISSN： 1792-0981 Impact factor: 2.447