| Literature DB >> 26996014 |
El'mira F Khusnutdinova, Irina E Smirnova, Gul'nara V Giniyatullina, Natal'ya I Medvedeva, Emil Yu Yamansarov, Dmitri V Kazakov, Oxana B Kazakova, Pham T Linh, Do Quoc Viet, DoThi Thu Huong.
Abstract
A variety of new and earlier synthesized lupane, oleanane, ursane and dammarane triterpenoids have been investigated for their inhibitory activity against α-glucosidase. 2,3-Indole-21 β-acetyl-20β,28-epoxy-18α,19βH-ursane and 3-oxo-3A-homo-3a-aza-20(S)-hydroxydammar-24(25)-ene were synthesized for the first time. The compounds 3, 4, 8-11 and 14 demonstrated strong in vitro inhibitory activity towards α-glucosidase with IC₅₀ values of 37.5-115.1 µM. 3-Deoxy-3a-homo-3a-aza-28-cinnamoyloxy-20(29)-lupene, with an IC₅₀ of 6.67 µM was 60-fold more active than the market drug acarbose.Entities:
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Year: 2016 PMID： 26996014
Source DB: PubMed Journal: Nat Prod Commun ISSN： 1555-9475 Impact factor: 0.986